Description
Specifications Table
Product Name – 17-AAG (17-Allylamino-17-Demethoxygeldanamycin) | TC409-5MG
Quantity/Pack Size – 5 mg
Form – Powder
Grade – Research Grade
Application – Protein Degradation Studies
Product Overview
17-AAG (17-Allylamino-17-Demethoxygeldanamycin) is a potent inhibitor of the heat shock protein 90 (HSP90), a molecular chaperone that plays a crucial role in the stability and function of numerous client proteins involved in signal transduction, cell cycle regulation, and apoptosis. This compound is widely used in research to study the mechanisms of protein degradation and its implications in various diseases, including cancer. 17-AAG selectively binds to HSP90, leading to the degradation of its client proteins, which can disrupt cellular pathways and induce apoptosis in cancer cells. Its high specificity and efficacy make it a valuable tool for researchers investigating the role of HSP90 in cellular processes and disease pathogenesis. The compound is supplied in a stable powder form, ensuring long-term storage and ease of use in laboratory settings.
FAQs
1. What is the primary application of 17-AAG (17-Allylamino-17-Demethoxygeldanamycin)?
17-AAG is primarily used in protein degradation studies, specifically targeting the heat shock protein 90 (HSP90).
2. Is 17-AAG compatible with other lab reagents?
Yes, 17-AAG is compatible with most standard lab reagents used in protein studies.
3. Are there any alternatives to 17-AAG for HSP90 inhibition?
Yes, other HSP90 inhibitors like geldanamycin and radicicol can be used as alternatives.
4. How should 17-AAG be stored?
17-AAG should be stored at -20°C in a dry, dark environment to maintain its stability and efficacy.
5. Where can I source high-quality 17-AAG?
High-quality 17-AAG can be sourced from reputable lab supply companies like eqipped.
