Description
Specifications Table
| Product Name | Fmoc-Glu(Odmab)-Oh |
|---|---|
| Quantity/Pack Size | 5 G |
| Form | Powder |
| Grade | Research Grade |
| Application | Peptide Synthesis |
Product Description
Fmoc-Glu(Odmab)-Oh is a high-quality protected glutamate derivative widely used in solid-phase peptide synthesis. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the alpha-amino function, while the Odmab (4,4′-dimethoxybenzyhydryl) group safeguards the gamma-carboxyl side chain. This combination ensures orthogonal deprotection strategies, making it a preferred choice for researchers synthesizing complex peptides.
This reagent is particularly valuable in the synthesis of peptides containing glutamic acid residues, where selective side-chain protection is critical. The Odmab group can be efficiently removed under mild acidic conditions, allowing for precise control over the synthesis process. Whether you’re working on therapeutic peptides, biochemical studies, or structural biology, Fmoc-Glu(Odmab)-Oh delivers consistent performance.
At eqipped, we source this product directly from Merck, ensuring you receive a reagent that meets the highest standards of purity and reliability. Each batch undergoes rigorous quality control to guarantee lot-to-lot consistency, so you can focus on your research without worrying about variability.
Need high-purity Fmoc-Glu(Odmab)-Oh for your peptide synthesis? Buy online now and get it delivered to your lab in India.
Key Applications
Fmoc-Glu(Odmab)-Oh is essential for researchers working in the following areas:
Peptide Synthesis: Ideal for introducing glutamic acid residues into peptides while maintaining side-chain protection during chain elongation.
Biochemical Research: Used in the synthesis of peptides for enzyme-substrate studies, protein-protein interaction research, and structural biology.
Therapeutic Peptides: Critical for developing peptide-based drugs where glutamic acid plays a functional or structural role.
Protein Mimics: Employed in the synthesis of peptide analogs that mimic natural proteins for functional studies.
If you’re looking for a reliable supplier of Fmoc-Glu(Odmab)-Oh in India, eqipped offers competitive pricing and fast shipping to ensure your research stays on track.
Handling and Storage
To maintain the integrity of Fmoc-Glu(Odmab)-Oh, store the product in a cool, dry place, away from direct sunlight and moisture. The reagent should be kept in a tightly sealed container to prevent degradation. For long-term storage, it is recommended to keep the product under inert gas, such as argon or nitrogen, to minimize oxidation.
When handling, use standard laboratory safety practices, including wearing appropriate personal protective equipment (PPE) such as gloves and safety goggles. Avoid inhaling dust or allowing the product to come into contact with skin or eyes. In case of accidental exposure, rinse thoroughly with water and seek medical attention if necessary.
Why This Product Stands Out
Fmoc-Glu(Odmab)-Oh from Merck is a top choice among researchers for several reasons. The Fmoc protection strategy is widely adopted in solid-phase peptide synthesis due to its stability under basic conditions and easy removal with mild acids. The Odmab group provides an additional layer of protection for the gamma-carboxyl, ensuring that the side chain remains intact during synthesis.
This product is designed for high coupling efficiency, reducing the risk of incomplete reactions that can complicate purification. The purity of the reagent minimizes the need for excessive washing steps, saving time and resources in the lab. Whether you’re synthesizing short peptides or complex proteins, Fmoc-Glu(Odmab)-Oh delivers the performance you need.
Order Fmoc-Glu(Odmab)-Oh 5g online today and experience the convenience of fast, reliable delivery from eqipped.
Compatibility with Synthesis Protocols
Fmoc-Glu(Odmab)-Oh is compatible with standard Fmoc-based solid-phase peptide synthesis protocols. It can be used with a variety of resins, including Wang, Rink Amide, and 2-chlorotrityl chloride resins, depending on the desired C-terminal functionality of the peptide. The reagent is also suitable for both manual and automated peptide synthesizers, making it versatile for different lab setups.
For optimal results, follow established coupling and deprotection protocols. The Fmoc group is typically removed using a solution of piperidine in DMF, while the Odmab group can be cleaved using trifluoroacetic acid (TFA) or other mild acidic conditions. Always refer to the specific synthesis protocol for your peptide sequence to ensure the best outcomes.
Safety and Regulatory Information
Fmoc-Glu(Odmab)-Oh is intended for research and laboratory use only. It is not for human or veterinary use. Handle the product in accordance with good laboratory practices and dispose of waste material in compliance with local regulations. For detailed safety information, refer to the Safety Data Sheet (SDS) provided by Merck.
If you’re unsure about the handling or disposal of this product, consult your institution’s environmental health and safety (EHS) guidelines or contact eqipped for assistance.
FAQs
What is the shelf life of Fmoc-Glu(Odmab)-Oh?
The shelf life of Fmoc-Glu(Odmab)-Oh is typically 24 months when stored under recommended conditions. Always check the expiration date on the product label and store it properly to maintain stability.
Can I use Fmoc-Glu(Odmab)-Oh in automated peptide synthesizers?
Yes, Fmoc-Glu(Odmab)-Oh is compatible with most automated peptide synthesizers that use Fmoc chemistry. Ensure that your synthesizer is calibrated for the specific coupling and deprotection steps required for this reagent.
How do I remove the Odmab protecting group?
The Odmab group can be removed using mild acidic conditions, such as a solution of trifluoroacetic acid (TFA) in dichloromethane (DCM). The exact conditions may vary depending on your synthesis protocol, so refer to your specific method for details.
Is Fmoc-Glu(Odmab)-Oh suitable for synthesizing phosphopeptides?
While Fmoc-Glu(Odmab)-Oh itself is not used for phosphopeptide synthesis, it can be incorporated into peptides that will later undergo phosphorylation. For direct phosphopeptide synthesis, you would need a phosphorylated glutamate derivative.
Where can I buy Fmoc-Glu(Odmab)-Oh in India?
You can buy Fmoc-Glu(Odmab)-Oh online from eqipped, a trusted supplier of high-quality lab reagents in India. We offer competitive pricing, fast shipping, and reliable customer support to ensure a seamless purchasing experience.
