Description
Specifications Table
| Product Name | Fmoc-His(Trt)-Oh |
|---|---|
| Quantity/Pack Size | 100 G |
| Form | Powder |
| Grade | Research |
| Application | Peptide synthesis, biochemical research |
Product Description
Fmoc-His(Trt)-OH 100 G | 8.52032.0100 | Merck is a premium-quality Fmoc-protected histidine derivative designed for solid-phase peptide synthesis (SPPS), peptide drug development, and advanced pharmaceutical research. Manufactured under strict quality standards, it offers high purity, excellent stability, and consistent performance for reliable peptide synthesis.
This protected amino acid is extensively used in medicinal chemistry, peptide synthesis, biochemical research, and life science applications. The 100 g pack is suitable for pharmaceutical companies, biotechnology laboratories, research institutes, universities, and industrial R&D facilities engaged in peptide production and research.
Merck Fmoc-His(Trt)-OH 100 G provides dependable quality and reproducible results for peptide chemistry, pharmaceutical innovation, and advanced scientific research.
FAQs
What is the difference between Fmoc-His(Trt)-Oh and Fmoc-His(Boc)-Oh?
The key difference lies in the side-chain protecting group. Fmoc-His(Trt)-Oh uses a trityl (Trt) group, which is acid-labile, while Fmoc-His(Boc)-Oh uses a Boc group, which is also acid-labile but less bulky. The choice depends on your synthesis strategy and compatibility with other protected amino acids in your sequence.
Can I use Fmoc-His(Trt)-Oh in microwave-assisted peptide synthesis?
Yes, Fmoc-His(Trt)-Oh is compatible with microwave-assisted SPPS. However, optimize the coupling time and temperature to avoid premature deprotection or side reactions. Typically, shorter coupling times (3-5 minutes) at 50-70°C work well.
How should I store Fmoc-His(Trt)-Oh to maximize shelf life?
Store the compound in a tightly sealed container under inert gas (argon or nitrogen) at -20°C. Minimize exposure to air and moisture, as the Trt group can be sensitive to acidic conditions. eqipped’s packaging is designed to preserve stability during shipping.
Is Fmoc-His(Trt)-Oh suitable for synthesizing histidine-rich peptides?
Absolutely. The Trt protecting group is particularly useful for histidine-rich sequences, as it prevents side reactions during coupling steps. This ensures high yields and purity, even in peptides with multiple histidine residues.
What is the typical coupling efficiency of Fmoc-His(Trt)-Oh?
With proper activation (e.g., using HBTU/HOBt or DIC/Oxyma), coupling efficiencies typically exceed 99%. Double coupling may be recommended for sequences with sterically hindered residues or when synthesizing long peptides.
