Description
Specifications Table
| Product Name | Fmoc-Hyp(Tbu)-Oh |
|---|---|
| Quantity/Pack Size | 5 GM |
| Form | Solid |
| Grade | Reagent Grade |
| Application | Peptide Synthesis |
Product Description
Fmoc-Hyp(Tbu)-Oh is a crucial building block in peptide synthesis, particularly valued for its ability to incorporate hydroxyproline residues while maintaining side-chain protection. This Merck product features the tert-butyl (Tbu) protecting group on the hydroxyl moiety, ensuring stability during synthesis while allowing for selective deprotection when needed.
The Fmoc (9-fluorenylmethoxycarbonyl) group provides temporary N-terminal protection that can be easily removed under mild basic conditions, making it ideal for solid-phase peptide synthesis protocols. Researchers working on collagen-like peptides or other hydroxyproline-rich sequences will find this compound particularly useful.
When you buy Fmoc-Hyp(Tbu)-Oh from eqipped, you’re getting a product that meets strict quality standards for peptide chemistry applications. Our supply chain ensures proper storage and handling to maintain the integrity of this sensitive compound.
Key Applications in Research
This protected amino acid derivative finds extensive use in:
1. Synthesis of collagen-mimetic peptides where hydroxyproline content is critical for triple-helix formation
2. Preparation of bioactive peptides requiring post-translational modification analogs
3. Development of peptide-based therapeutics where secondary structure stability is important
4. Academic research projects studying protein folding and peptide conformation
The Tbu protecting group offers excellent stability against the conditions typically used in Fmoc-based synthesis, while remaining compatible with standard deprotection protocols using trifluoroacetic acid.
Handling and Storage Recommendations
To maintain optimal performance of your Fmoc-Hyp(Tbu)-Oh:
Store at -20°C in a desiccated environment
Avoid repeated freeze-thaw cycles
Use in a well-ventilated fume hood when handling
Protect from moisture and light exposure
For best results in peptide synthesis, use fresh, high-quality solvents and reagents. The purity of your starting materials directly impacts the success of your synthesis.
Why This Product Stands Out
Merck’s Fmoc-Hyp(Tbu)-Oh offers several advantages for peptide chemists:
The combination of Fmoc and Tbu protection allows for orthogonal deprotection strategies
High purity ensures minimal side reactions during coupling steps
Consistent batch-to-batch quality supports reproducible research results
Optimized for compatibility with automated peptide synthesizers
Whether you’re working on fundamental research or developing peptide-based therapeutics, having reliable access to high-quality protected amino acids is essential. eqipped makes it easy to buy Fmoc-Hyp(Tbu)-Oh online with convenient delivery options across India.
Ready to enhance your peptide synthesis workflow? Buy Fmoc-Hyp(Tbu)-Oh 5g today for your next research project.
Safety Information
While Fmoc-Hyp(Tbu)-Oh is generally considered safe for laboratory use, proper handling procedures should be followed:
Wear appropriate personal protective equipment (lab coat, gloves, safety glasses)
Avoid inhalation of dust or vapors
In case of skin contact, wash thoroughly with soap and water
Dispose of according to local chemical waste regulations
FAQs
What is the molecular weight of Fmoc-Hyp(Tbu)-Oh?
The molecular weight is approximately 411.47 g/mol, though this may vary slightly depending on the specific batch and any residual solvents.
Can this product be used in automated peptide synthesizers?
Yes, Fmoc-Hyp(Tbu)-Oh is fully compatible with standard automated peptide synthesis protocols using Fmoc chemistry.
What is the typical coupling efficiency for this amino acid derivative?
With proper activation and coupling conditions, you can expect coupling efficiencies of 99% or higher when using standard coupling reagents like HATU or DIC/HOBt.
How should I store opened containers of Fmoc-Hyp(Tbu)-Oh?
Once opened, the product should be stored under inert atmosphere (argon or nitrogen) at -20°C with desiccant to prevent moisture absorption and degradation.
Does eqipped offer bulk quantities of Fmoc-Hyp(Tbu)-Oh?
While this listing is for the 5g pack size, we can arrange larger quantities upon request. Contact our customer service team for bulk pricing and availability.
