Description
Specifications Table
| Product Name | Fmoc-Leu-(Dmb)Gly-Oh |
|---|---|
| Pack Size | 5 G |
| Form | Powder |
| Grade | Research Grade |
| Application | Peptide Synthesis |
Product Description
Fmoc-Leu-(Dmb)Gly-Oh is a specialized FMOC-protected amino acid derivative designed for high-efficiency peptide synthesis. This compound features a Dmb (2,4-dimethoxybenzyl) protecting group on the glycine residue, ensuring stability during coupling reactions while allowing selective deprotection under mild conditions. Ideal for researchers and labs working on complex peptide sequences, this product guarantees consistent results with minimal side reactions.
Whether you’re synthesizing therapeutic peptides, biochemical probes, or custom sequences, Fmoc-Leu-(Dmb)Gly-Oh from Merck delivers the purity and performance required for demanding applications. The FMOC protection strategy is widely adopted in solid-phase peptide synthesis (SPPS) due to its orthogonal compatibility with other protecting groups, making this product a versatile choice for both academic and industrial settings.
At eqipped, we prioritize quality and reliability, sourcing this product directly from Merck to ensure authenticity. Our streamlined ordering process and pan-India delivery make it easier than ever to access premium lab supplies without compromise.
Upgrade your peptide synthesis workflow with Fmoc-Leu-(Dmb)Gly-Oh. Order today for precise, reproducible results.
Key Applications
This FMOC-protected amino acid is particularly useful for:
- Solid-phase peptide synthesis (SPPS) requiring orthogonal protection strategies.
- Synthesis of peptides with post-translational modifications or unnatural amino acids.
- Research involving glycopeptides or other complex biomolecules.
Handling and Storage
Store Fmoc-Leu-(Dmb)Gly-Oh in a cool, dry place away from direct sunlight. For long-term storage, keep the container tightly sealed and maintain temperatures between 2°C and 8°C. Avoid exposure to moisture or oxidizing agents to preserve integrity.
Safety Information
While this product is generally safe for lab use, standard precautions for handling fine chemicals apply. Wear appropriate personal protective equipment (PPE), including gloves and safety goggles, when working with the powder. In case of skin or eye contact, rinse thoroughly with water and seek medical advice if irritation persists.
FAQs
What is the role of the Dmb protecting group in Fmoc-Leu-(Dmb)Gly-Oh?
The Dmb (2,4-dimethoxybenzyl) group protects the glycine residue, allowing selective deprotection under acidic conditions without affecting the FMOC group. This orthogonal protection is critical for multi-step peptide synthesis.
Can this product be used in automated peptide synthesizers?
Yes, Fmoc-Leu-(Dmb)Gly-Oh is compatible with most automated SPPS systems. Its solubility and coupling efficiency make it suitable for both manual and automated workflows.
What is the typical coupling time for this amino acid derivative?
Under standard SPPS conditions, coupling times range from 30 to 60 minutes, depending on the activator used (e.g., HATU, DIC/HOBt). Optimization may be required for sterically hindered sequences.
How does eqipped ensure the authenticity of this Merck product?
We source directly from Merck’s authorized distributors and maintain strict quality control checks. Each batch includes a certificate of analysis (CoA) for verification.
What is the shelf life of Fmoc-Leu-(Dmb)Gly-Oh?
When stored as recommended, the product remains stable for at least 24 months from the date of manufacture. Always check the expiration date on the label.
