Description
Specifications Table
| Product Name | Fmoc-Thr-Oh |
|---|---|
| Quantity/Pack Size | 25 G |
| Form | Powder |
| Grade | Peptide Synthesis Grade |
| Application | Solid-Phase Peptide Synthesis (SPPS) |
Product Description
Fmoc-Thr-Oh, also known as Fmoc-L-Threonine, is a high-purity protected amino acid derivative essential for peptide synthesis. This compound features an Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which is widely used in solid-phase peptide synthesis (SPPS) due to its stability and ease of removal under mild conditions. The hydroxyl group of threonine is left unprotected, allowing for selective coupling in peptide chains.
Researchers and students working in biochemistry, pharmacology, and molecular biology rely on Fmoc-Thr-Oh for synthesizing peptides with precise sequences. Its high purity ensures minimal side reactions, making it a preferred choice for both academic and industrial applications. Whether you’re developing therapeutic peptides or studying protein interactions, this reagent delivers consistent results.
At eqipped, we source Fmoc-Thr-Oh directly from Merck, ensuring authenticity and batch-to-batch reliability. Our streamlined supply chain guarantees that you receive your order quickly, so your research stays on track. Need Fmoc-Thr-Oh for your next synthesis? Order now and experience hassle-free delivery across India.
Why Fmoc-Thr-Oh Matters in Peptide Synthesis
Peptide synthesis requires careful selection of protected amino acids to avoid unwanted reactions. Fmoc-Thr-Oh stands out because:
It uses the Fmoc protecting group, which is base-labile and compatible with orthogonal protection strategies. This allows for step-by-step assembly of peptides without damaging sensitive side chains.
The free hydroxyl group on threonine enables post-synthetic modifications, such as glycosylation or phosphorylation, which are critical for mimicking natural peptides.
Its solubility in common organic solvents like DMF and DCM makes it easy to handle in automated synthesizers, reducing manual errors.
For students learning SPPS techniques, Fmoc-Thr-Oh serves as a reliable building block to master coupling and deprotection steps. Educators often include it in lab modules to demonstrate the importance of protecting groups in organic synthesis.
Applications of Fmoc-Thr-Oh
This versatile reagent finds use in various research areas:
Drug Discovery: Synthetic peptides derived from Fmoc-Thr-Oh are used to screen potential drug candidates, especially in anticancer and antiviral research.
Protein Engineering: Incorporating threonine residues helps study post-translational modifications and their effects on protein function.
Vaccine Development: Peptide-based vaccines often require threonine-containing epitopes to elicit strong immune responses.
Structural Biology: Researchers use customized peptides to investigate protein-protein interactions and enzyme mechanisms.
If you’re working on any of these projects, having a dependable supplier for Fmoc-Thr-Oh is crucial. eqipped ensures you get Merck’s high-quality product without delays.
Handling and Storage Guidelines
To maintain the integrity of Fmoc-Thr-Oh, follow these best practices:
Store the unopened container at -20°C to prevent degradation. Once opened, keep it in a desiccator to avoid moisture absorption.
Use in a well-ventilated fume hood, as DMF and other solvents used in SPPS can be hazardous.
Avoid prolonged exposure to light, as the Fmoc group is sensitive to photodegradation.
Always wear appropriate personal protective equipment (PPE), including gloves and goggles, when handling the powder.
For long-term storage, aliquot the reagent into smaller portions to minimize freeze-thaw cycles.
Safety Considerations
While Fmoc-Thr-Oh is generally safe when handled properly, it’s important to note:
This product is for research use only and not intended for human or animal consumption.
In case of skin or eye contact, rinse immediately with plenty of water and seek medical advice if irritation persists.
Dispose of waste material in accordance with local regulations for chemical waste.
FAQs
What is the purity of Fmoc-Thr-Oh from Merck?
The Fmoc-Thr-Oh supplied by Merck typically has a purity of ≥99%, as determined by HPLC. This high purity ensures reliable results in peptide synthesis.
Can I use Fmoc-Thr-Oh for automated peptide synthesizers?
Yes, Fmoc-Thr-Oh is fully compatible with most automated SPPS systems. Its solubility in DMF and DCM makes it ideal for machine-based synthesis.
How should I store Fmoc-Thr-Oh to extend its shelf life?
Store the product at -20°C in a tightly sealed container. For best results, use a desiccant to prevent moisture absorption after opening.
Is Fmoc-Thr-Oh suitable for Fmoc/tBu chemistry?
Absolutely. Fmoc-Thr-Oh is designed for Fmoc/tBu chemistry, the most common strategy in solid-phase peptide synthesis.
Where can I buy Fmoc-Thr-Oh online in India?
You can purchase authentic Fmoc-Thr-Oh 25g from eqipped, a trusted supplier of Merck products. We offer competitive pricing and fast shipping across India.
