Description
Specifications Table
| Product Name | FMOC-L-Glu(OtBu)-OH | TC1662 | CDH |
|---|---|
| Pack Size | 5 gm, 25 gm, 100 gm, 1 kg |
| Form | Powder |
| Grade | Reagent Grade |
| Application | Peptide synthesis, biochemical research |
Product Description
FMOC-L-Glu(OtBu)-OH is a high-quality protected amino acid derivative widely used in peptide synthesis. This compound features an FMOC (9-fluorenylmethoxycarbonyl) protecting group on the alpha-amino function and a tert-butyl ester (OtBu) on the side chain carboxyl group. The combination ensures stability during synthesis while allowing selective deprotection under mild conditions.
Researchers and students working in biochemistry, pharmaceutical development, or proteomics rely on FMOC-L-Glu(OtBu)-OH for its purity and consistency. The tert-butyl ester protection prevents unwanted side reactions, making it ideal for solid-phase peptide synthesis (SPPS). Whether you’re synthesizing complex peptides or studying protein interactions, this reagent delivers reliable results.
At eqipped, we source FMOC-L-Glu(OtBu)-OH from trusted manufacturers to ensure batch-to-batch consistency. Our packaging options (5 gm to 1 kg) cater to both small-scale lab experiments and larger research projects. Need bulk quantities for your lab? Contact us for customized pricing and fast shipping across India.
Key Applications
FMOC-L-Glu(OtBu)-OH is primarily used in:
- Solid-phase peptide synthesis (SPPS)
- Synthesis of glutamic acid-containing peptides
- Biochemical research requiring protected amino acids
- Pharmaceutical development of peptide-based drugs
Why This Product Stands Out
Unlike generic alternatives, this FMOC-protected glutamic acid derivative offers superior solubility in organic solvents like DMF and DCM, critical for efficient coupling reactions. The tert-butyl ester group remains stable under standard FMOC deprotection conditions (e.g., piperidine in DMF), allowing orthogonal deprotection strategies.
Students and researchers appreciate its high coupling efficiency, reducing the need for excess reagents and minimizing side products. For labs focused on reproducibility, this product’s consistent purity (typically >98% by HPLC) ensures reliable experimental outcomes.
Handling and Storage
Store FMOC-L-Glu(OtBu)-OH in a cool, dry place away from direct sunlight. For long-term storage, keep the container tightly sealed and consider desiccants to prevent moisture absorption. Always handle in a well-ventilated fume hood, as FMOC-protected amino acids can be sensitive to light and humidity.
Safety Information
Risk Note: FMOC-L-Glu(OtBu)-OH is for laboratory use only. Avoid inhalation, ingestion, or skin contact. Wear appropriate PPE (gloves, lab coat, safety goggles) when handling. In case of contact, rinse thoroughly with water and seek medical advice if irritation persists.
FAQs
What is FMOC-L-Glu(OtBu)-OH used for?
It’s primarily used in peptide synthesis as a protected L-glutamic acid derivative. The FMOC group protects the alpha-amino function, while the tert-butyl ester protects the side chain carboxyl group.
How do I deprotect FMOC-L-Glu(OtBu)-OH?
The FMOC group is typically removed using 20% piperidine in DMF. The tert-butyl ester requires stronger acidic conditions (e.g., TFA) for deprotection.
What solvents work best for dissolving this compound?
FMOC-L-Glu(OtBu)-OH is soluble in organic solvents like DMF, DCM, and DMSO. Avoid aqueous solutions unless specifically required for your protocol.
Can I use this for Fmoc-based solid-phase peptide synthesis?
Yes, this is a standard reagent for Fmoc-SPPS. Its orthogonal protection allows selective deprotection during synthesis.
What pack sizes are available at eqipped?
We offer 5 gm, 25 gm, 100 gm, and 1 kg packs to suit different research needs. Order now to get the best FMOC L Glutamic Acid price in India.
