Specifications Table

Product Name – Phenyl chloroformate
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – ACS reagent
Application – Organic synthesis, derivatization, peptide coupling

Product Overview

Phenyl chloroformate is a highly reactive reagent widely used in organic synthesis for derivatization and peptide coupling reactions. This ACS reagent-grade compound ensures high purity and consistency, making it suitable for demanding laboratory applications. Its molecular structure allows for efficient formation of phenyl carbamates and ureas, which are critical intermediates in pharmaceutical and biochemical research. The liquid form provides ease of handling and precise dosing, while its stability under standard storage conditions ensures long shelf life. Phenyl chloroformate reacts readily with amines and alcohols, enabling the synthesis of complex organic molecules with high yields. The reagent’s versatility extends to applications in analytical chemistry, where it serves as a derivatizing agent for GC-MS and HPLC analysis. Proper handling and storage are essential due to its moisture-sensitive nature, which can lead to hydrolysis if exposed to atmospheric conditions. Researchers and chemists rely on this compound for its predictable reactivity and compatibility with a wide range of solvents, making it a staple in synthetic laboratories.

FAQs

1. What is the primary application of phenyl chloroformate in organic synthesis?

Phenyl chloroformate is primarily used for derivatization reactions, peptide coupling, and the synthesis of phenyl carbamates and ureas.

2. Is this reagent compatible with aqueous solutions?

No, phenyl chloroformate hydrolyzes rapidly in the presence of water, so it should be handled under anhydrous conditions.

3. What are the recommended storage conditions for phenyl chloroformate?

Store in a cool, dry place under inert gas, away from moisture and heat sources to prevent decomposition.

4. Can phenyl chloroformate be used as an alternative to other chloroformates?

Yes, it can replace alkyl chloroformates in many applications, though reactivity may vary based on the specific reaction.

5. What safety precautions should be taken when handling this reagent?

Use in a fume hood with proper PPE, as it is corrosive and can release toxic fumes upon reaction with moisture.