Description
Specifications Table
Product Name – Trimethylchlorosilane
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – Laboratory Grade (98%+ purity)
Application – Silylation reagent for organic synthesis, derivatization
Product Overview
Trimethylchlorosilane is a highly reactive organosilicon compound widely used as a silylation reagent in organic chemistry. This colorless to pale yellow liquid features a sharp, pungent odor and boasts a minimum purity of 98%, ensuring reliable performance in laboratory applications. The compound’s primary function involves converting active hydrogen groups (such as alcohols, amines, and carboxylic acids) into their corresponding trimethylsilyl derivatives, thereby enhancing volatility and thermal stability for gas chromatography and mass spectrometry analysis. Its moisture-sensitive nature demands careful handling under anhydrous conditions, typically in a fume hood with proper ventilation. The reagent demonstrates excellent solubility in common organic solvents like hexane, toluene, and dichloromethane, while reacting violently with water to produce hydrochloric acid. Storage requires airtight containers in cool, dry environments away from incompatible substances. This laboratory-grade Trimethylchlorosilane serves as an essential building block in organosilicon chemistry, offering consistent reactivity for derivatization processes where precise molecular modifications are critical.
FAQs
1. What safety precautions should be taken when handling Trimethylchlorosilane?
Always use in a well-ventilated fume hood with proper personal protective equipment including gloves, goggles, and lab coat. The compound is highly corrosive and reacts violently with water, releasing hydrochloric acid fumes. Avoid inhalation and skin contact.
2. Can this reagent be used for protecting hydroxyl groups in carbohydrates?
Yes, Trimethylchlorosilane effectively converts hydroxyl groups into trimethylsilyl ethers, which is particularly useful for protecting sugar hydroxyls in carbohydrate chemistry before further synthetic steps.
3. What is the typical shelf life of unopened Trimethylchlorosilane?
When stored properly in its original sealed container at room temperature in a dry environment, unopened Trimethylchlorosilane maintains its specified purity for approximately 24 months from the date of manufacture.
4. How should I dispose of waste containing Trimethylchlorosilane?
Neutralize small quantities by slow addition to a large volume of ice-cold sodium bicarbonate solution in a fume hood. For larger quantities, consult local hazardous waste disposal regulations or contact professional chemical waste disposal services.
5. What alternatives exist for less reactive silylation applications?
For milder silylation conditions, consider using N,O-bis(trimethylsilyl)acetamide (BSA) or N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), which offer similar functionality with reduced reactivity compared to Trimethylchlorosilane.
