Description

Specifications Table

Product Name – 1-Pentanesulfonic acid, sodium salt HPLC
Quantity/Pack Size – 25 g
Form – Solid (Powder/Crystalline)
Grade – HPLC
Application – Ion-pair chromatography, reversed-phase HPLC

Product Overview

1-Pentanesulfonic acid sodium salt is a high-purity, HPLC-grade ion-pair reagent designed for precise chromatographic separations in analytical and preparative applications. This compound acts as a hydrophobic counterion, enhancing retention and selectivity for ionic or ionizable analytes in reversed-phase HPLC systems. Its low UV absorbance ensures minimal interference with detection, making it ideal for sensitive analyses. The sodium salt form improves solubility in aqueous mobile phases, allowing seamless integration into existing HPLC protocols. With a molecular weight of 188.22 g/mol and a CAS number of 22767-50-6, this reagent undergoes rigorous quality control to meet strict HPLC standards, ensuring reproducibility and accuracy in separations. The solid form (powder or crystalline) offers stability during storage and handling, while its compatibility with common organic modifiers like acetonitrile and methanol further expands its utility. Whether used in isocratic or gradient elution, this reagent provides consistent performance across a wide pH range (2.0–7.5), making it a versatile choice for method development and routine analysis.

FAQs

1. What is the primary function of 1-Pentanesulfonic acid sodium salt in HPLC?

It serves as an ion-pairing agent to improve retention and separation of ionic or polar compounds in reversed-phase HPLC by forming neutral ion pairs with analytes.

2. Is this reagent compatible with mass spectrometry (LC-MS) applications?

While it can be used, its non-volatile nature may cause ion suppression or source contamination, so volatile alternatives like trifluoroacetic acid are often preferred for LC-MS.

3. How should this product be stored for long-term stability?

Store in a tightly sealed container at room temperature (15–25°C), protected from moisture and light to prevent degradation or hydration.

4. Can this reagent be used with gradient elution in HPLC?

Yes, it is compatible with gradient elution, but the ion-pair concentration should remain constant to avoid retention time shifts during the gradient.

5. What alternatives exist for ion-pair chromatography if this reagent is unavailable?

Alternatives include heptanesulfonic acid sodium salt, octanesulfonic acid sodium salt, or tetrabutylammonium salts, depending on the analyte’s hydrophobicity and charge.