Description
Specifications Table
Product Name – o-Tolylmagnesium bromide, 2M solution in diethyl ether, AcroSeal® Quantity/Pack Size – 100ML Form – Liquid (solution in diethyl ether) Grade – Reagent Grade Application – Organic synthesis, Grignard reactions
Product Overview
o-Tolylmagnesium bromide, supplied as a 2M solution in diethyl ether under the AcroSeal® packaging, is a highly reactive Grignard reagent essential for carbon-carbon bond formation in organic synthesis. The solution is stabilized in anhydrous diethyl ether to prevent premature decomposition, ensuring consistent performance in moisture-sensitive applications. The AcroSeal® technology provides an airtight seal, minimizing exposure to atmospheric moisture and oxygen, which can degrade the reagent. This formulation is ideal for laboratory-scale reactions requiring precise stoichiometry and high purity. The reagent’s ortho-tolyl group introduces steric and electronic effects that influence reaction selectivity, making it valuable for synthesizing complex organic molecules. As a 2M solution, it offers a balanced concentration for controlled addition in synthetic protocols. The product is rigorously tested for halogen content and solubility, meeting reagent-grade specifications for reproducibility in research and development settings.
FAQs
1. What is the shelf life of o-Tolylmagnesium bromide 2M solution in diethyl ether?
The shelf life is typically 12 months from the date of manufacture when stored unopened under recommended conditions. The AcroSeal® packaging helps extend stability by reducing exposure to moisture.
2. Is this reagent compatible with standard glassware for Grignard reactions?
Yes, it is compatible with dry, moisture-free glassware. Ensure all equipment is thoroughly dried and flushed with inert gas to prevent side reactions with residual moisture.
3. Can this solution be used as a substitute for phenylmagnesium bromide in synthesis?
While structurally similar, the ortho-methyl group in o-tolylmagnesium bromide alters reactivity and selectivity. It may not be a direct substitute without adjusting reaction conditions or expecting different product distributions.
4. How should this reagent be stored to maintain its reactivity?
Store the sealed bottle at 2–8°C in a dry, inert atmosphere. Avoid prolonged exposure to light or heat, and keep away from ignition sources due to the flammable diethyl ether solvent.
5. What precautions are necessary when handling this Grignard reagent?
Handle under a fume hood with proper PPE, including gloves and goggles. The solution is highly flammable and reacts violently with water, releasing hydrogen gas. Use only in dry conditions with inert gas purging.
