Description
Specifications Table
Product Name – Ammonia, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid solution
Grade – AcroSeal® (high-purity, moisture-sensitive)
Application – Organic synthesis, nucleophilic reactions, ammonia-derived transformations
Product Overview
This 0.5M ammonia solution in tetrahydrofuran (THF) is a specialized reagent designed for applications demanding strict anhydrous conditions and precise ammonia delivery. The AcroSeal® packaging ensures minimal moisture ingress, preserving the solution’s integrity and reactivity over extended storage periods. THF serves as an ideal solvent for ammonia due to its ability to dissolve polar and nonpolar compounds while maintaining solution stability. The controlled 0.5M concentration provides consistent stoichiometry in reactions, eliminating the need for dilution or concentration adjustments. This solution is particularly valuable in organic synthesis where ammonia acts as a nucleophile or base, enabling cleaner reactions with reduced side-product formation. The high-purity grade minimizes metallic and anionic impurities that could interfere with catalytic systems or sensitive analytical techniques. Compatible with standard glassware and inert atmosphere setups, this solution integrates seamlessly into existing lab workflows without requiring specialized handling equipment beyond basic moisture control measures.
FAQs
1. Can this ammonia-THF solution be used directly in Grignard reactions?
The 0.5M concentration is suitable for many Grignard reactions, though you may need to adjust stoichiometry based on your specific substrate. The THF solvent is compatible with most Grignard reagents, but always verify reaction conditions with your protocol.
2. What precautions should be taken when storing this solution long-term?
Store unopened bottles in a cool, dry place under inert gas if possible. Once opened, reseal immediately using the AcroSeal® cap and purge with nitrogen or argon to prevent moisture absorption. Avoid temperature fluctuations that could compromise the seal integrity.
3. How does this compare to ammonia solutions in other solvents like methanol?
THF offers better solubility for organic substrates compared to methanol, making it preferable for nonpolar reaction systems. However, methanol-based solutions may be more suitable for reactions requiring protic solvents or where THF’s peroxide formation potential is a concern.
4. Is this solution compatible with air-sensitive catalysts?
The AcroSeal® packaging maintains low oxygen and moisture levels, but for ultra-sensitive catalysts, additional purging with inert gas before use is recommended. The solution itself does not contain stabilizers that might interfere with catalytic activity.
5. What’s the typical shelf life for unopened bottles?
When stored properly in original packaging at room temperature, the solution remains stable for 12-18 months. The AcroSeal® technology significantly extends shelf life compared to conventional packaging by minimizing solvent evaporation and atmospheric contamination.
