Description
Specifications Table
Product Name – Benzyl chloroformate, 3M (50 wt.%) solution in toluene, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid
Grade – Reagent
Application – Organic synthesis, peptide protection
Product Overview
Benzyl chloroformate, supplied as a 3M (50 wt.%) solution in toluene, is a versatile reagent widely used in organic synthesis for introducing benzyl protecting groups. The AcroSeal® packaging ensures minimal exposure to moisture and air, preserving the reagent’s reactivity and extending shelf life. This high-purity solution is particularly valued for its efficiency in peptide synthesis, where selective protection of amino groups is critical. The toluene solvent provides an optimal balance of solubility and stability, making it suitable for a range of laboratory conditions. Researchers benefit from its consistent performance in esterification and carbamate formation reactions. The reagent’s controlled concentration allows for precise dosing, reducing waste and improving reproducibility in experimental protocols. Its compatibility with standard laboratory equipment and protocols makes it a preferred choice for both small-scale and larger synthetic applications.
FAQs
1. What is the shelf life of benzyl chloroformate solution?
The shelf life is approximately 12 months when stored unopened in its original AcroSeal® packaging at recommended conditions.
2. Is this solution compatible with glassware?
Yes, the toluene-based solution is compatible with standard borosilicate glass laboratory equipment.
3. What precautions should be taken during handling?
Use in a well-ventilated fume hood with appropriate PPE, as both components are volatile and potentially hazardous.
4. Can this reagent be used for large-scale synthesis?
While primarily designed for lab-scale applications, the 100ML packaging allows for multiple reactions when scaled appropriately.
5. What alternatives exist for similar applications?
Alternatives include Fmoc-Cl or Boc anhydride, though each offers different protection/deprotection profiles.
