Specifications Table

Product Name – [Bis(2-methOxyethyl)aminO]sulfur trifluOride, 2.7M (5O wt.%) sOlutiOn in toluene, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid (solution in toluene)
Grade – Reagent grade
Application – Fluorination reagent in organic synthesis

Product Overview

[Bis(2-methoxyethyl)amino]sulfur trifluoride (2.7M in toluene) is a specialized fluorinating agent designed for selective fluorination reactions in organic synthesis. This 50 wt.% solution leverages the AcroSeal® packaging system to ensure moisture-sensitive stability and prolonged shelf life. The reagent’s unique structure combines sulfur trifluoride with bis(2-methoxyethyl)amine, enabling milder reaction conditions compared to traditional fluorinating agents like DAST or Deoxo-Fluor. The toluene solvent provides compatibility with a wide range of organic substrates while maintaining reagent reactivity. Ideal for applications requiring precise fluorine incorporation, this solution minimizes side reactions such as rearrangements or eliminations, which are common with harsher fluorinating agents. The reagent’s liquid form allows for easy handling and accurate dosing via syringe or pipette. Store under inert atmosphere and at recommended temperatures to preserve potency. Equipped’s offering ensures consistent batch-to-batch performance, critical for reproducible research outcomes.

FAQs

1. What is the shelf life of this [Bis(2-methoxyethyl)amino]sulfur trifluoride solution when stored properly?

When stored unopened in its original AcroSeal® packaging under inert gas at 2–8°C, the reagent retains its specified potency for at least 12 months from the date of manufacture. Avoid exposure to moisture or air to prevent degradation.

2. Can this reagent be used as a direct replacement for DAST or Deoxo-Fluor in existing protocols?

While it serves similar fluorination purposes, the reactivity profile differs due to the bis(2-methoxyethyl)amine moiety. Pilot-scale optimization is recommended to adjust reaction times, temperatures, and stoichiometry for equivalent yields.

3. What precautions should be taken when handling this toluene-based solution?

Handle in a well-ventilated fume hood with standard organic solvent precautions. Toluene is flammable and may cause skin/eye irritation; use nitrile gloves, safety goggles, and avoid inhalation. The reagent itself is moisture-sensitive and corrosive.

4. Is this solution compatible with glass reaction vessels, or are special materials required?

The solution is compatible with borosilicate glassware, though PTFE-lined or polypropylene equipment is preferred for prolonged contact to minimize potential leaching or reactivity with glass surfaces over time.

5. How does the 50 wt.% concentration compare to neat sulfur trifluoride reagents in terms of reactivity?

The diluted form (2.7M in toluene) offers controlled reactivity, reducing the risk of violent exotherms or over-fluorination associated with neat reagents. This makes it suitable for substrates sensitive to harsh conditions, though reaction times may be longer.