Description

Specifications Table

Product Name – tert-Butylchlorodiphenylsilane, 98%, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid
Grade – 98%
Application – Silylating agent for protecting groups

Product Overview

tert-Butylchlorodiphenylsilane (98%) is a highly reactive silylating agent widely used in organic synthesis for the protection of hydroxyl, amino, and carboxylic acid functional groups. Its bulky tert-butyl and phenyl substituents provide exceptional steric hindrance, making it ideal for selective protection in complex molecules. The AcroSeal® packaging ensures long-term stability by minimizing exposure to moisture, which is critical for maintaining the reagent’s reactivity. This compound is particularly valued for its ability to form stable silyl ethers that withstand a variety of reaction conditions, including basic and mildly acidic environments. The high purity (98%) guarantees consistent performance in sensitive applications, reducing the risk of side reactions. Its liquid form allows for easy handling and precise dosing, making it a preferred choice for laboratory-scale syntheses. Whether used in multi-step organic synthesis or as a protective group in peptide chemistry, this reagent delivers reliability and efficiency, ensuring reproducible results in demanding experimental setups.

FAQs

1. What is the primary application of tert-Butylchlorodiphenylsilane?

It is primarily used as a silylating agent to protect hydroxyl, amino, and carboxylic acid groups during organic synthesis.

2. How should this reagent be stored to maintain its stability?

Store in a cool, dry place under inert gas (e.g., nitrogen or argon) and keep the container tightly sealed to prevent moisture absorption.

3. Is this compound compatible with aqueous reaction conditions?

No, it reacts with water and should be used in anhydrous conditions to avoid decomposition.

4. What alternatives exist for protecting hydroxyl groups?

Alternatives include tert-Butyldimethylsilyl chloride (TBSCl) and Triisopropylsilyl chloride (TIPSCl), which offer varying levels of steric bulk and stability.