Description
Specifications Table
Product Name – Cyclopropylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid (THF solution)
Grade – Reagent
Application – Grignard reagent for cyclopropane synthesis
Product Overview
Cyclopropylmagnesium bromide is a highly reactive Grignard reagent supplied as a 0.5M solution in tetrahydrofuran (THF). The AcroSeal® packaging ensures air and moisture resistance, preserving the reagent’s stability during storage and handling. This reagent is specifically formulated for applications requiring cyclopropyl group introduction, offering consistent reactivity in organic synthesis. The THF solvent enhances solubility and compatibility with polar substrates, while the 0.5M concentration balances reactivity with ease of dosing. The reagent is sealed under nitrogen to prevent degradation, making it ideal for long-term storage without compromising performance. Its high purity minimizes side reactions, ensuring reliable results in sensitive transformations. The solution is free from stabilizers that could interfere with downstream applications, providing a clean reagent for precise synthetic work.
FAQs
1. What is the shelf life of Cyclopropylmagnesium bromide in THF?
The reagent remains stable for 12 months when stored unopened at 2-8°C under nitrogen. Always check for precipitation or discoloration before use.
2. Can this reagent be used with water-sensitive substrates?
Yes, the AcroSeal® packaging maintains anhydrous conditions, but ensure all glassware and substrates are thoroughly dried before use to prevent side reactions.
3. Are there alternatives for cyclopropane synthesis?
Cyclopropyl lithium or zinc-based reagents can be alternatives, but they may require different reaction conditions and offer varying yields.
4. How should I store opened bottles?
Seal tightly under nitrogen, store at 2-8°C, and use within 3 months. Avoid repeated exposure to air to prevent degradation.
5. Is this reagent compatible with polar aprotic solvents?
It is soluble in THF and ether but may decompose in protic solvents like alcohols or water. Test compatibility for mixed solvent systems.
