Description
Specifications Table
Product Name – 3,4-Difluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML
Form – Solution in THF
Grade – AcroSeal® (air/moisture-sensitive)
Application – Organic synthesis, Grignard reactions
Product Overview
This 0.5M 3,4-difluorophenylmagnesium bromide solution in THF is a highly reactive Grignard reagent designed for precision organic synthesis. The AcroSeal® packaging ensures maximum protection against air and moisture contamination, preserving reagent integrity for consistent performance. The difluoro substitution on the phenyl ring enhances reactivity while maintaining selectivity in carbon-carbon bond formation. The THF solvent provides optimal solubility and reaction kinetics. This reagent is particularly valuable for synthesizing fluorinated aromatic compounds, where the fluorine substituents impart unique electronic and steric properties. The solution is stabilized under inert conditions and should be handled using standard Schlenk techniques to prevent decomposition. Each batch undergoes rigorous quality control to guarantee concentration accuracy and minimal impurities. The amber glass bottle with PTFE-lined cap provides additional protection against light and atmospheric exposure.
FAQs
1. What precautions should be taken when handling this Grignard reagent?
Always work under an inert atmosphere (nitrogen/argon) using dry glassware. Avoid exposure to air or moisture as it reacts violently with water. Use appropriate PPE including gloves and safety goggles.
2. Can this solution be stored long-term?
For optimal stability, store unopened at 2-8°C under inert gas. Once opened, use within 6 months while maintaining strict moisture exclusion. Long-term storage may lead to gradual decomposition.
3. What’s the typical reaction temperature range for this reagent?
Most reactions proceed efficiently between -78°C to room temperature, though optimal conditions depend on the specific substrate. Lower temperatures help control exothermic reactions.
4. How does the difluoro substitution affect reactivity compared to non-fluorinated analogs?
The electron-withdrawing fluorine atoms reduce the nucleophilicity slightly but increase the reagent’s stability. The ortho-fluoro position also enables potential directing effects in subsequent transformations.
5. What’s the best way to transfer this solution for reactions?
Use a dry syringe or cannula under positive inert gas pressure. Pre-cool the reagent if working at low temperatures to minimize solvent evaporation during transfer.
