Specifications Table

Product Name – (1,3-Dioxan-2-ylethyl)magnesium bromide, 0.5M solution in THF, AcroSeal® Quantity/Pack Size – 50ML Form – Liquid (THF solution) Grade – Reagent grade Application – Grignard reagent for organic synthesis

Product Overview

(1,3-Dioxan-2-ylethyl)magnesium bromide is a specialized Grignard reagent supplied as a 0.5M solution in tetrahydrofuran (THF), designed for high-efficiency organic synthesis. The AcroSeal® packaging ensures air-tight protection, preventing moisture contamination that could degrade the reagent’s reactivity. This solution maintains precise molar concentration, critical for reproducible results in carbon-carbon bond formation, nucleophilic additions, and other organometallic reactions. The THF solvent enhances solubility and reactivity while minimizing side reactions, making it a preferred choice for complex synthetic routes. The reagent’s stability under inert conditions allows for extended shelf life when stored properly, though it requires careful handling due to its moisture-sensitive nature. Compatible with standard Schlenk techniques and glove-box environments, this solution is optimized for researchers requiring consistent performance in air-sensitive chemistry. The reagent’s structure, featuring a protected aldehyde equivalent, enables selective transformations in multi-step syntheses.

FAQs

1. What precautions should be taken while handling this Grignard reagent?

Always work under an inert atmosphere (argon/nitrogen) using dry glassware. Avoid exposure to moisture or air, as the reagent reacts violently with water. Use standard Schlenk line techniques or a glove box for transfers.

2. Can this solution be used directly without further purification?

The 0.5M solution is provided in reagent-grade purity and is typically used as-received. However, if your application demands ultra-high purity, you may titrate the solution to confirm concentration before use.

3. What is the typical shelf life of this product when stored correctly?

When stored unopened in its original AcroSeal® packaging at room temperature under inert conditions, the solution remains stable for 12–18 months. Opened bottles should be resealed and used within 3–6 months.

4. Is this reagent compatible with other common organic solvents?

The solution is pre-dissolved in THF, which is optimal for most Grignard reactions. Avoid mixing with protic solvents (e.g., alcohols, water) or chlorinated solvents, which may cause decomposition or side reactions.

5. How does the AcroSeal® packaging improve reagent stability?

The AcroSeal® system uses a septum-sealed bottle with a threaded cap, creating an airtight barrier. This design prevents moisture ingress and solvent evaporation, preserving the reagent’s concentration and reactivity over time.