Description
Specifications Table
Product Name – Iodotrimethylsilane, 95-97%, stabilized, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid
Grade – Reagent, 95-97%
Application – Silylating agent, organic synthesis, deprotection reactions
Product Overview
Iodotrimethylsilane (TMSI) is a highly reactive silylating reagent supplied at 95-97% purity with AcroSeal® stabilization to ensure consistent performance in moisture-sensitive applications. This clear, colorless to pale yellow liquid is widely recognized for its efficiency in cleaving alkyl and aryl ethers, esters, and other protective groups under mild conditions. The stabilized formulation minimizes decomposition during storage, extending shelf life while maintaining reactivity. Its low boiling point (106-108°C) enables easy removal post-reaction, simplifying purification processes. The reagent’s high iodine content enhances its nucleophilic substitution capabilities, making it particularly effective for converting alcohols to alkyl iodides or for desilylation reactions. Packaged in a 100ML AcroSeal® bottle, this product is designed for precise dispensing and reduced exposure to atmospheric moisture. The reagent-grade purity ensures minimal byproduct formation, critical for high-yield syntheses in research and analytical laboratories.
FAQs
1. What is the typical shelf life of stabilized Iodotrimethylsilane?
The AcroSeal® stabilization extends the shelf life to 12-18 months when stored unopened at 2-8°C, though reactivity may gradually decrease after opening due to moisture absorption.
2. Can this reagent be used for deprotecting tert-butyldimethylsilyl (TBS) ethers?
Yes, Iodotrimethylsilane is highly effective for cleaving TBS ethers under mild conditions, often at room temperature or with gentle heating, producing the corresponding alcohols.
3. What precautions should be taken when handling this chemical?
Always use in a fume hood with proper PPE (gloves, goggles, lab coat) due to its corrosive nature and potential to release toxic hydrogen iodide gas upon moisture contact.
4. Is this product compatible with glass reaction vessels?
While compatible with glass, prolonged exposure may etch the surface; use PTFE-lined or plasticware for extended reactions to prevent contamination.
5. How does the AcroSeal® packaging improve product stability?
The AcroSeal® bottle features a moisture-resistant barrier and a resealable cap that minimizes air exposure, reducing hydrolysis and preserving the reagent’s potency.
