Specifications Table

Product Name – [4-(4-Morpholinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (solution in THF)
Grade – Reagent Grade
Application – Organic synthesis, Grignard reactions, C-C bond formation

Product Overview

[4-(4-Morpholinylmethyl)phenyl]magnesium bromide is a 0.25M Grignard reagent solution in tetrahydrofuran (THF), designed for high-efficiency organic synthesis applications. This air- and moisture-sensitive reagent is supplied in an AcroSeal® bottle, ensuring stability and minimizing exposure to atmospheric contaminants. The morpholinylmethyl phenyl structure enables selective reactivity in carbon-carbon bond formation, making it ideal for synthesizing complex organic intermediates. The reagent is standardized to 0.25M concentration, providing consistent stoichiometry for reproducible results. THF, the solvent, enhances solubility and reactivity while maintaining compatibility with most organic reaction conditions. The AcroSeal® packaging features a septum cap for safe, controlled dispensing without compromising the reagent’s integrity. This product is particularly valued for its purity, precise molarity, and the convenience of pre-dissolved form, eliminating the need for in-house preparation. Store under inert gas (argon/nitrogen) at 2–8°C to preserve reactivity and extend shelf life.

FAQs

1. What precautions should be taken while handling this Grignard reagent?

This reagent is highly air- and moisture-sensitive. Always work under an inert atmosphere (argon/nitrogen) using dry glassware. Avoid exposure to water or protic solvents, as it can decompose violently. Use in a well-ventilated fume hood with appropriate PPE, including gloves and goggles.

2. Is this reagent compatible with other common organic solvents besides THF?

The reagent is supplied in THF due to its optimal solubility and reactivity. While it may dissolve in ethers like diethyl ether or 2-methylTHF, avoid protic solvents (e.g., alcohols, water) or chlorinated solvents (e.g., dichloromethane), which can quench the reagent or cause side reactions.

3. Can this be used as a direct substitute for similar Grignard reagents like phenylmagnesium bromide?

While structurally related, the morpholinylmethyl group introduces distinct steric and electronic effects, altering reactivity and selectivity. Test compatibility in your specific reaction, as yields or side products may differ compared to simpler aryl Grignard reagents.

4. How should the AcroSeal® bottle be stored to maintain reagent quality?

Store the sealed bottle at 2–8°C under inert gas (do not vent). Avoid freeze-thaw cycles, as THF can absorb moisture. Keep away from ignition sources, as THF vapors are flammable. Once opened, use promptly or re-seal under inert gas to prevent degradation.

5. What is the typical shelf life of this reagent when stored properly?

When unopened and stored at 2–8°C under inert conditions, the reagent retains its specified molarity for 12–18 months. After opening, use within 3–6 months for optimal performance, though titration is recommended to verify concentration before critical applications.