Specifications Table

Product Name – [3-(1-Pyrrolidinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Synthesis grade
Application – Organic synthesis, Grignard reactions

Product Overview

[3-(1-Pyrrolidinylmethyl)phenyl]magnesium bromide is a 0.25M Grignard reagent solution in anhydrous THF, packaged under nitrogen in an AcroSeal® bottle to prevent moisture contamination. This organomagnesium compound is widely used in carbon-carbon bond formation, enabling efficient synthesis of complex organic molecules. The pyrrolidinylmethyl substituent enhances reactivity while maintaining selectivity in nucleophilic addition reactions. The THF solvent ensures optimal solubility and reaction kinetics, making it suitable for both small-scale and preparative chemistry. The AcroSeal® packaging features a resealable septum cap, allowing multiple withdrawals without compromising reagent integrity. Each batch undergoes rigorous purity testing to ensure consistent performance in synthetic applications. The solution remains stable when stored under inert conditions, with minimal degradation over time. This reagent is particularly valuable for synthesizing pharmaceutical intermediates, fine chemicals, and specialty materials where precise control over reaction conditions is required.

FAQs

1. What precautions should be taken when handling this Grignard reagent?

Always work under inert atmosphere (nitrogen/argon) in a fume hood. Use oven-dried glassware and avoid exposure to moisture or air to prevent violent reactions.

2. Can this reagent be used with other solvents besides THF?

The solution is specifically formulated in THF for optimal reactivity. Transferring to other solvents may cause precipitation or altered reaction kinetics.

3. How does the AcroSeal® packaging improve reagent stability?

The nitrogen-filled headspace and septum cap system prevents moisture ingress during storage and multiple withdrawals, maintaining reagent potency.

4. What is the typical shelf life of this product when stored properly?

When stored at recommended conditions (2-8°C under inert atmosphere), the reagent maintains ≥95% activity for 12 months from date of manufacture.

5. Are there any known incompatibilities with common functional groups?

This Grignard reagent reacts violently with protic solvents, carbonyl compounds, and acidic functional groups. Always verify compatibility before use.