Specifications Table

Product Name – Trimethylboroxine, 3.5M (50 wt.%) solution in THF, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid (Solution in THF)
Grade – Reagent Grade
Application – Boron reagent for organic synthesis, catalyst precursor

Product Overview

Trimethylboroxine, supplied as a 3.5M (50 wt.%) solution in tetrahydrofuran (THF), is a highly reactive boron compound designed for precision applications in organic synthesis. The AcroSeal® packaging ensures minimal exposure to moisture and air, preserving the reagent’s purity and reactivity over extended storage periods. This solution offers a convenient alternative to solid trimethylboroxine, providing consistent molar concentration for reproducible results in boron-mediated transformations. The THF solvent enhances solubility and compatibility with a wide range of organic substrates, making it particularly useful in Suzuki-Miyaura cross-couplings, hydroboration, and other boron-dependent reactions. The reagent’s controlled concentration eliminates the need for in-house dilution, reducing preparation time and potential errors. Its low moisture content (<50 ppm) and sealed packaging prevent hydrolysis, ensuring reliable performance in moisture-sensitive protocols. The clear, colorless solution allows for easy visual inspection of purity, while its stable shelf life under inert conditions makes it a practical choice for both small-scale and bulk applications.

FAQs

1. What is the exact molarity of this trimethylboroxine solution?

The solution is standardized at 3.5M (50 wt.%), with the molarity verified via titration against a primary standard to ensure accuracy for stoichiometric calculations.

2. Can this solution be used directly in air-sensitive reactions?

While the AcroSeal® packaging minimizes air exposure, we recommend transferring the solution under inert gas (N₂/Ar) for highly air-sensitive applications to prevent oxidative degradation.

3. What alternatives exist for boron reagents in THF?

Alternatives include boron trifluoride etherate (BF₃·OEt₂) for Lewis acid catalysis or trialkylboranes (e.g., triethylborane) for hydroboration, though these differ in reactivity and selectivity profiles.

4. How should this solution be stored for long-term stability?

Store unopened at 2–8°C in a desiccator or under inert gas. Once opened, reseal tightly and use within 6 months for optimal performance, avoiding prolonged exposure to humidity.

5. Is this solution compatible with glassware, or are special materials required?

The solution is compatible with standard borosilicate glassware. For prolonged storage or reactions, PTFE-lined caps are recommended to prevent solvent evaporation and contamination.