Specifications Table

Product Name – (Trimethylsilyl)diazomethane, technical, approx. 2.0M solution in hexanes, AcroSeal®
Quantity/Pack Size – 100ML
Form – Solution
Grade – Technical
Application – Methylating agent, diazo transfer reactions

Product Overview

(Trimethylsilyl)diazomethane (TMS-diazomethane) is a versatile methylating reagent supplied as a 2.0M solution in hexanes for enhanced stability and ease of handling. This technical-grade solution is packaged in AcroSeal® bottles, ensuring airtight protection against moisture and oxygen, which is critical for maintaining reagent integrity. The solution is widely recognized for its efficiency in diazo transfer reactions, enabling the introduction of diazo functionality under mild conditions. The hexane solvent system provides compatibility with a broad range of organic solvents, making it suitable for diverse synthetic applications. As a silyl-protected diazomethane derivative, it offers improved safety compared to free diazomethane while retaining high reactivity. The AcroSeal® packaging further minimizes exposure risks during storage and dispensing. This reagent is particularly valued for its ability to generate diazo compounds in situ, avoiding the need for hazardous gas handling. The technical grade ensures cost-effectiveness without compromising performance in most laboratory applications.

FAQs

1. What is the shelf life of (Trimethylsilyl)diazomethane in hexanes?

The solution remains stable for 12-18 months when stored unopened at 2-8°C in its original AcroSeal® packaging. Always check for discoloration or precipitate formation before use, as these indicate decomposition.

2. Can this reagent be used as a direct substitute for diazomethane?

While it serves similar purposes, (Trimethylsilyl)diazomethane requires in situ activation (typically with methanol or fluoride sources) to generate the active diazo species. Reaction conditions may need optimization compared to gaseous diazomethane.

3. What precautions are necessary when handling this solution?

Always work in a well-ventilated fume hood due to potential diazomethane generation. Use compatible gloves (nitrile recommended) and avoid glassware with ground joints, as diazo compounds can form explosive azides with metal contaminants.

4. How should disposal of unused solution be handled?

Neutralize with dilute acetic acid (1:10 v/v) in a fume hood until gas evolution ceases, then dispose according to local regulations for halogenated organic waste. Never discard untreated solution.

5. What alternatives exist for methyl esterification reactions?

For less sensitive applications, consider trimethylsilyldiazomethane (2.0M in ether) or diazald® kits. For non-diazo approaches, methyl iodide or dimethyl sulfate may be suitable, though with different reactivity profiles.