Description
Specifications Table
Product Name – n-Butyllithium, 2.5M in hexane Quantity/Pack Size – 800ML Form – Solution in hexane Grade – Research grade Application – Organic synthesis, deprotonation, polymerization
Product Overview
n-Butyllithium 2.5M in hexane is a highly reactive organolithium reagent widely used in organic synthesis for deprotonation, metal-halogen exchange, and polymerization reactions. This solution is stabilized in hexane to maintain its potency and ensure consistent performance in lab applications. The 2.5M concentration provides a balanced reactivity profile, making it suitable for both small-scale and bulk synthesis. As an air- and moisture-sensitive compound, it requires strict handling under inert conditions to prevent degradation. The reagent is supplied in a sealed container to preserve its purity and reactivity. Its high nucleophilicity and strong basicity make it indispensable for creating carbon-carbon bonds and functional group transformations. Researchers rely on this reagent for its reliability in producing high yields in complex organic reactions. Proper storage and handling are critical to maintaining its efficacy.
FAQs
1. What precautions should be taken while handling n-Butyllithium?
Handle under an inert atmosphere (nitrogen/argon) using dry syringes or cannulas. Avoid exposure to air, moisture, or heat, as it can ignite spontaneously.
2. Can this reagent be used for metal-halogen exchange reactions?
Yes, n-Butyllithium is commonly used for metal-halogen exchange, particularly with aryl and alkyl halides, to generate organolithium intermediates.
3. What is the shelf life of n-Butyllithium 2.5M in hexane?
When stored unopened at 2-8°C under inert conditions, it retains potency for up to 12 months. Check for discoloration or precipitation before use.
4. Is this reagent compatible with glassware?
Yes, but ensure the glassware is dry and free of moisture. Use PTFE or rubber septa to maintain an inert environment during transfers.
5. Are there safer alternatives for less experienced users?
For beginners, lithium diisopropylamide (LDA) or n-butyllithium in lower concentrations (1.6M) may offer better control with reduced hazard risks.
