Specifications Table

Product Name – N,N-DIMETHYL FORMAMIDE 99.8% GC-HS
Quantity/Pack Size – 1000 ml, 2500 ml
Form – Liquid
Grade – 99.8% GC-HS
Application – Solvent for organic synthesis, HPLC, spectroscopy, and pharmaceutical intermediates

Product Overview

N,N-Dimethyl Formamide (DMF) 99.8% GC-HS is a high-purity, polar aprotic solvent widely used in laboratory and industrial applications due to its exceptional solvating power and thermal stability. This grade is refined through gas chromatography-headspace (GC-HS) analysis to ensure minimal impurities, including water content below 0.05%, making it suitable for moisture-sensitive reactions. Its low volatility and high boiling point (153°C) allow for prolonged use in elevated-temperature processes without significant evaporation loss. The solvent exhibits excellent miscibility with water and most organic solvents, facilitating homogeneous reaction mixtures in peptide synthesis, polymer dissolution, and electrophilic substitutions. Its high dielectric constant (36.7) enhances the dissolution of ionic and polar compounds, while its hygroscopic nature necessitates proper storage to maintain purity. This DMF variant is stabilized to prevent degradation into dimethylamine and formic acid, ensuring consistent performance in critical applications. Compatible with glass, stainless steel, and PTFE, it is non-corrosive to standard lab equipment when handled under recommended conditions.

FAQs

1. What is the shelf life of N,N-Dimethyl Formamide 99.8% GC-HS when stored unopened?

The unopened product has a shelf life of 24 months from the date of manufacture when stored in a cool, dry place away from direct sunlight and moisture. Always check the batch-specific expiration date on the label.

2. Can this DMF grade be used for HPLC mobile phase preparation?

Yes, the 99.8% GC-HS grade is suitable for HPLC applications due to its low UV absorbance and minimal impurity profile. However, we recommend filtering through a 0.22µm membrane before use to remove potential particulate matter.

3. What precautions should be taken when handling this solvent?

DMF is a skin and respiratory irritant with potential systemic toxicity. Always use in a well-ventilated fume hood, wear nitrile gloves, safety goggles, and a lab coat. Avoid inhalation of vapors and prolonged skin contact, as it can enhance absorption of other chemicals.

4. Is this product compatible with plastic containers for long-term storage?

While DMF is compatible with HDPE and PTFE for short-term use, we recommend glass or stainless steel containers for long-term storage to prevent potential leaching or permeability issues that may compromise purity.

5. How does the GC-HS certification differ from standard analytical grades?

GC-HS (Gas Chromatography-Headspace) certification specifically verifies ultra-low levels of volatile impurities and residual solvents, which is critical for applications like gas chromatography, mass spectrometry, or reactions sensitive to trace contaminants. Standard analytical grades may not undergo this rigorous headspace analysis.