Description

Specifications Table

Product Name – HBTU 97% For Synthesis Quantity/Pack Size – 5 g, 25 g, 100 g Form – Solid (Powder/Crystals) Grade – Synthesis Grade (97% Purity) Application – Peptide Coupling, Organic Synthesis

Product Overview

HBTU (O-Benzotriazole-N,N,N’,N’-tetramethyl-uronium-hexafluoro-phosphate) is a highly efficient coupling reagent widely used in peptide synthesis due to its superior reactivity and minimal racemization. This 97% pure grade ensures optimal performance in both solid-phase and solution-phase peptide synthesis, making it a preferred choice for researchers and chemists. The reagent facilitates amide bond formation by activating carboxyl groups, enabling high-yield coupling reactions. Its stability under standard lab conditions and compatibility with common solvents like DMF and DCM further enhance its utility. HBTU is particularly valued for its ability to minimize side reactions, ensuring cleaner synthesis outcomes. Whether used in manual or automated peptide synthesizers, this reagent delivers consistent results, reducing the need for excessive purification steps. The 97% purity level guarantees reliable performance, making it suitable for demanding applications in organic and medicinal chemistry.

FAQs

1. What is the shelf life of HBTU 97% when stored properly?

When stored in a cool, dry place away from moisture and light, HBTU 97% typically retains its efficacy for up to 2 years from the date of manufacture. Always check the container for any signs of degradation before use.

2. Can HBTU 97% be used with Fmoc-based peptide synthesis?

Yes, HBTU 97% is fully compatible with Fmoc (9-fluorenylmethyloxycarbonyl) chemistry, making it a versatile choice for both manual and automated peptide synthesis protocols.

3. What are the key safety precautions while handling HBTU?

HBTU should be handled in a fume hood with appropriate personal protective equipment (PPE), including gloves and goggles. Avoid inhalation or direct contact, as it may cause irritation. Dispose of waste according to local chemical safety regulations.

4. Is HBTU 97% soluble in common organic solvents?

Yes, HBTU 97% is soluble in polar organic solvents such as DMF (N,N-Dimethylformamide) and DCM (Dichloromethane), which are commonly used in peptide synthesis.

5. How does HBTU compare to other coupling reagents like HATU or DCC?

HBTU offers a balance between cost and efficiency, providing high coupling yields with lower racemization risks compared to DCC. While HATU is more potent for challenging couplings, HBTU remains a cost-effective alternative for routine peptide synthesis.

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