Description
Specifications Table
Product Name – Isopropylmagnesium chloride, 2.0M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (Solution in THF)
Grade – Reagent Grade (2.0M Concentration)
Application – Grignard reagent for organic synthesis, carbon-carbon bond formation
Product Overview
Isopropylmagnesium chloride, supplied as a 2.0M solution in tetrahydrofuran (THF), is a highly reactive Grignard reagent essential for organic synthesis applications requiring precise nucleophilic additions or carbon-carbon bond formation. The reagent is stabilized in anhydrous THF, a polar aprotic solvent that enhances its solubility and reactivity while minimizing side reactions such as proton abstraction or solvent coordination. Packaged under nitrogen in AcroSeal® bottles, this solution is protected from moisture and oxygen, ensuring long-term stability and consistent performance in air-sensitive reactions. The 2.0M concentration provides an optimal balance between reagent strength and ease of handling, reducing the need for excessive solvent volumes in large-scale syntheses. Its reagent-grade purity guarantees minimal impurities, such as residual magnesium or chloride ions, which could interfere with reaction yields or selectivity. The AcroSeal® packaging features a tamper-evident cap and a septum for syringe extraction, enabling controlled dispensing without exposure to atmospheric contaminants. This formulation is particularly suited for applications demanding strict anhydrous conditions, such as the preparation of complex organic intermediates, pharmaceutical precursors, or specialty chemicals. The THF solvent is distilled and dried to meet rigorous laboratory standards, further ensuring reproducibility in critical reactions.
FAQs
1. What precautions should be taken when handling Isopropylmagnesium chloride in THF?
Always work under an inert atmosphere (nitrogen/argon) in a fume hood, as the reagent is highly moisture-sensitive and pyrophoric. Use flame-dried glassware and avoid contact with water or protic solvents to prevent violent reactions or decomposition. Wear appropriate PPE, including gloves and safety goggles, due to its corrosive nature.
2. Is this reagent compatible with other common laboratory solvents?
The 2.0M solution is specifically formulated in THF, which is optimal for Grignard reactions. Avoid mixing with protic solvents (e.g., alcohols, water) or polar solvents like DMSO, which may decompose the reagent. Ether-based solvents (e.g., diethyl ether) can be used for dilution if anhydrous conditions are maintained.
3. How does the AcroSeal® packaging improve the reagent’s shelf life?
The AcroSeal® bottle features a hermetic seal and a septum cap designed to prevent moisture ingress and oxygen exposure. The nitrogen-purged headspace minimizes degradation, while the tamper-evident closure ensures the reagent remains uncontaminated until first use. Store upright and unopened for maximum stability.
4. Can this reagent be used as a substitute for other alkylmagnesium halides?
Yes, but reactivity may vary based on the alkyl group. Isopropylmagnesium chloride offers steric bulk compared to methyl or ethyl Grignards, which can influence reaction rates and selectivity. Test small-scale reactions first to assess compatibility with your specific synthesis, especially in sterically hindered substrates.
5. What is the recommended storage temperature for this solution?
Store at 2–8°C in a tightly sealed original container, away from heat sources and direct sunlight. Avoid freezing, as THF may precipitate or alter the reagent’s homogeneity. For long-term storage, keep the bottle under inert gas and minimize headspace to reduce solvent evaporation.
