Description
Specifications Table
Product Name – Lithium tri-tert-butoxyaluminohydride, 1.1M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid solution
Grade – Laboratory reagent
Application – Selective reduction reagent in organic synthesis
Product Overview
Lithium tri-tert-butoxyaluminohydride (LTBA) is a highly selective reducing agent supplied as a 1.1M solution in tetrahydrofuran (THF) under the AcroSeal® system to ensure moisture-free stability and extended shelf life. This reagent is renowned for its ability to perform chemoselective reductions, particularly in converting esters, lactones, and carboxylic acids to their corresponding alcohols while preserving sensitive functional groups like alkenes, alkynes, and nitriles. The THF solvent enhances solubility and reactivity, making it a preferred choice for complex synthetic routes. Packaged in airtight, septum-sealed bottles, this solution minimizes exposure to atmospheric moisture, which is critical for maintaining reagent potency. The 1.1M concentration offers a balance between reactivity and ease of handling, reducing the need for excessive solvent use. Ideal for applications requiring precise control over reduction outcomes, this product is a staple in advanced organic synthesis laboratories. The AcroSeal® packaging further ensures safe storage and convenient dispensing, reducing waste and contamination risks.
FAQs
1. What is the primary advantage of using Lithium tri-tert-butoxyaluminohydride over LiAlH4?
Lithium tri-tert-butoxyaluminohydride offers superior chemoselectivity compared to LiAlH4, reducing esters and carboxylic acids without affecting alkenes, alkynes, or nitriles, which are often reactive under LiAlH4 conditions.
2. Can this reagent be used with protic solvents?
No, this reagent is incompatible with protic solvents like water or alcohols, as it reacts violently with them. THF is the recommended solvent for optimal performance.
3. How should this solution be stored for long-term stability?
Store the sealed bottle in a cool, dry place under inert gas (e.g., nitrogen or argon) to prevent moisture absorption. Avoid temperature fluctuations and direct sunlight.
4. Is this product compatible with glassware, or are special materials required?
The solution can be used with standard borosilicate glassware, but ensure all equipment is thoroughly dried and free of residual moisture or protic contaminants.
5. What safety precautions are necessary when handling this reagent?
Wear nitrile gloves, safety goggles, and a lab coat. Work in a fume hood due to the reagent’s reactivity with air and moisture. Quench spills carefully with isopropanol or a suitable alcohol.
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