Description
Specifications Table
Product Name – Methylmagnesium chloride, 3M (22 wt.%) solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – Laboratory reagent grade
Application – Grignard reagent for organic synthesis
Product Overview
Methylmagnesium chloride, 3M (22 wt.%) solution in THF, AcroSeal® is a highly reactive Grignard reagent designed for demanding organic synthesis applications. This air- and moisture-sensitive solution is stabilized in tetrahydrofuran (THF) to maintain its 3M concentration, ensuring consistent performance in halogen-metal exchange reactions, nucleophilic additions, and carbon-carbon bond formation. The AcroSeal® packaging guarantees minimal exposure to atmospheric moisture, preserving reagent integrity during storage and handling. Its 22 wt.% concentration balances reactivity with practical solubility, making it suitable for both small-scale and bulk synthesis. The THF solvent enhances compatibility with a wide range of organic substrates while minimizing side reactions. This reagent is particularly valued for its ability to generate complex organomagnesium intermediates with high yield and selectivity. Proper handling under inert conditions is essential to prevent decomposition and ensure reproducible results in synthetic protocols.
FAQs
1. What precautions are needed when handling this methylmagnesium chloride solution?
Always work under an inert atmosphere (nitrogen/argon) using dry glassware. The solution is highly flammable and reacts violently with water, releasing methane gas. Wear flame-resistant lab coats, gloves, and safety goggles. Use in a well-ventilated fume hood to avoid inhalation of THF vapors.
2. Can this reagent be used directly for carbonylation reactions?
Yes, but the THF solvent must be compatible with your carbonylation conditions. For CO gas insertions, ensure your reaction setup is pressurized and moisture-free. The 3M concentration provides sufficient nucleophilicity for carbonylative coupling, though some protocols may require dilution for better selectivity control.
3. How does the AcroSeal® packaging improve shelf life compared to standard bottles?
The AcroSeal® system uses a septum-sealed design that prevents air ingress during repeated punctures. Unlike screw-cap bottles that risk moisture contamination with each opening, this packaging maintains reagent purity for up to 12 months when stored at 2-8°C. The septum also allows syringe extraction without exposing the bulk solution to atmosphere.
4. What’s the typical moisture content threshold for solvents used with this Grignard reagent?
Solvents should contain less than 50 ppm water. Even trace moisture will decompose the reagent into methane and magnesium hydroxide, reducing yield. Pre-dry solvents over molecular sieves (4Å) or use freshly distilled THF from sodium/benzophenone for critical applications. Karl Fischer titration can verify solvent dryness before use.
5. Are there alternatives for reactions requiring lower nucleophilicity than methylmagnesium chloride?
For milder conditions, consider ethylmagnesium bromide (1M in THF) or isopropylmagnesium chloride (2M in THF). These offer similar reactivity but with slightly reduced basicity. For sterically hindered substrates, bulkier Grignard reagents like tert-butylmagnesium chloride may improve selectivity, though they require higher temperatures for complete conversion.
