Specifications Table

Product Name – 1-Propynylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – Reagent grade
Application – Organic synthesis, Grignard reactions

Product Overview

1-Propynylmagnesium bromide is a highly reactive Grignard reagent supplied as a 0.5M solution in tetrahydrofuran (THF), ensuring optimal solubility and stability for organic synthesis applications. The AcroSeal® packaging technology prevents moisture contamination, preserving the reagent’s reactivity and extending shelf life. This solution is particularly valuable for introducing propynyl groups into organic molecules, enabling the synthesis of complex compounds with terminal alkynes. The THF solvent enhances the reagent’s compatibility with a wide range of substrates, making it a versatile choice for laboratory-scale reactions. The reagent’s high purity minimizes side reactions, ensuring consistent and reproducible results. Whether used in nucleophilic additions or carbon-carbon bond formations, this solution delivers reliable performance for demanding synthetic routes.

FAQs

1. What precautions should be taken when handling 1-Propynylmagnesium bromide?

Handle under inert gas (nitrogen/argon) to prevent moisture exposure. Use flame-resistant gloves and work in a fume hood due to THF’s flammability.

2. Is this reagent compatible with polar aprotic solvents?

It is pre-dissolved in THF, but can be used with solvents like diethyl ether or toluene if transferred under anhydrous conditions.

3. What alternatives exist for propynylation reactions?

Ethynylmagnesium bromide or lithium acetylides can be used, but may require different reaction conditions or yield profiles.

4. How should this solution be stored long-term?

Store at 2–8°C in the original AcroSeal® bottle, tightly sealed, and away from ignition sources. Avoid freeze-thaw cycles.

5. Can this reagent be used for large-scale synthesis?

The 800ML pack size supports scaled reactions, but pilot testing is recommended to optimize stoichiometry and quenching protocols.