Specifications Table

Product Name – (Trimethylsilyl)methyllithium, 0.7M (10 wt%) solution in hexanes, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution in hexanes)
Grade – Synthesis grade
Application – Organolithium reagent for silylation, C-C bond formation

Product Overview

(Trimethylsilyl)methyllithium is a highly reactive organolithium reagent supplied as a 0.7M (10 wt%) solution in hexanes, packaged under AcroSeal® technology to ensure moisture-free stability during storage and handling. This solution is widely utilized in organic synthesis for introducing trimethylsilyl (TMS) groups, enabling selective silylation of alcohols, amines, and other functional groups. The hexanes solvent system provides optimal solubility while maintaining reagent activity, making it ideal for sensitive reactions requiring anhydrous conditions. The AcroSeal® packaging minimizes exposure to atmospheric moisture, extending shelf life and reducing waste from degradation. With precise molarity control, this reagent delivers consistent performance in lithiation, nucleophilic addition, and deprotonation reactions. Researchers benefit from its high purity and reliable batch-to-batch reproducibility, critical for scaling synthetic protocols. Store under inert gas at 2–8°C to preserve reactivity, and handle in a fume hood with standard organolithium precautions.

FAQs

1. What is the typical shelf life of (Trimethylsilyl)methyllithium in hexanes?

When stored unopened under AcroSeal® at 2–8°C, the solution retains full potency for 12–18 months. Opened bottles should be used within 3–6 months for optimal reactivity.

2. Can this reagent be used for deprotonating acidic C-H bonds?

Yes, the strong basicity of (Trimethylsilyl)methyllithium makes it effective for deprotonating weakly acidic hydrocarbons, though reaction conditions may require optimization based on substrate.

3. Is this solution compatible with THF or ether as co-solvents?

The hexanes solution can be diluted with anhydrous THF or diethyl ether, but solubility and reactivity may vary. Pre-test small-scale reactions to confirm compatibility.

4. How should I dispose of excess (Trimethylsilyl)methyllithium solution?

Neutralize with isopropanol or a dilute acid solution (e.g., 1M HCl) in a fume hood, then follow local regulations for hazardous waste disposal of organolithium residues.

5. Are there alternatives to AcroSeal® packaging for smaller quantities?

For lab-scale use, sure-seal bottles or ampoules are alternatives, but AcroSeal® offers superior moisture protection for repeated access without inert gas purging.

—