Description
Specifications Table
| Product Name | 1,1′-Carbonyldiimidazole For Synthesis |
|---|---|
| Quantity/Pack Size | 5g |
| Form | Solid |
| Grade | For Synthesis |
| Application | Peptide synthesis, esterification, and amide formation |
Product Description
1,1′-Carbonyldiimidazole (CDI) is a versatile coupling agent widely used in organic synthesis, particularly for peptide bond formation and esterification reactions. This Merck-grade reagent ensures high purity and reliability, making it a preferred choice for researchers and students working in biochemical and pharmaceutical laboratories.
CDI activates carboxyl groups, enabling efficient amide and ester synthesis under mild conditions. Its stability and reactivity make it indispensable for synthesizing complex molecules, including pharmaceutical intermediates and bioactive peptides. Whether you’re conducting academic research or industrial-scale synthesis, this 5g pack provides sufficient quantity for multiple experiments.
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Key Applications
CDI is commonly used in:
- Peptide synthesis for activating amino acids
- Esterification of alcohols and carboxylic acids
- Formation of carbamates and ureas
- Pharmaceutical intermediate synthesis
Safety and Handling
As a reactive chemical, 1,1′-Carbonyldiimidazole should be handled with care. Always wear appropriate PPE (gloves, goggles, lab coat) and work in a well-ventilated area or fume hood. Avoid contact with skin, eyes, and clothing. Store in a cool, dry place away from moisture and incompatible substances.
FAQs
What is the shelf life of 1,1′-Carbonyldiimidazole?
When stored properly in a sealed container at room temperature, CDI has a shelf life of 2–3 years. Always check for signs of degradation before use.
Can this reagent be used for large-scale synthesis?
Yes, this 5g pack is suitable for both small-scale lab experiments and pilot-scale synthesis. For bulk requirements, eqipped offers larger quantities upon request.
Is 1,1′-Carbonyldiimidazole soluble in water?
No, CDI is insoluble in water but soluble in organic solvents like THF, DMF, and dichloromethane.
What are the alternatives to CDI for peptide synthesis?
Common alternatives include DCC (Dicyclohexylcarbodiimide) and EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide), but CDI is often preferred for its milder reaction conditions.
How do I dispose of unused CDI?
Follow local regulations for chemical waste disposal. Neutralize with a mild base (e.g., sodium bicarbonate) before disposal to minimize environmental impact.
