Specifications Table

Product Name – 1,1,1,3,3,3-Hexamethyldisilazane 98% For Synthesis
Quantity/Pack Size – 100 ml, 500 ml
Form – Liquid
Grade – For Synthesis
Application – Silylation reagent, derivatization, surface modification

Product Overview

1,1,1,3,3,3-Hexamethyldisilazane (HMDS) is a high-purity silylation reagent widely used in organic synthesis and analytical chemistry. This 98% grade compound is a colorless, volatile liquid with a strong ammonia-like odor, offering excellent reactivity for derivatizing polar functional groups. Its primary function is to replace active hydrogen atoms with trimethylsilyl groups, enhancing the volatility and thermal stability of compounds for gas chromatography (GC) and mass spectrometry (MS) applications. The reagent is highly effective in surface modification processes, particularly in microelectronics and semiconductor manufacturing, where it improves adhesion and moisture resistance. Due to its moisture-sensitive nature, HMDS must be stored under inert conditions to prevent hydrolysis. The synthesis-grade purity ensures minimal impurities, making it ideal for sensitive analytical procedures. Its low boiling point (125°C) allows for easy removal post-reaction, simplifying purification steps. Compatible with most organic solvents, HMDS serves as a versatile tool in both research and industrial laboratories for silylation reactions, though proper handling is required due to its corrosive and flammable properties.

FAQs

1. What is the primary application of 1,1,1,3,3,3-Hexamethyldisilazane in laboratories?

It is primarily used as a silylation reagent to derivatize polar functional groups, improving volatility for gas chromatography and mass spectrometry analysis.

2. Is this compound compatible with aqueous solutions?

No, 1,1,1,3,3,3-Hexamethyldisilazane reacts violently with water, releasing ammonia and forming hexamethyldisiloxane. It should be stored under dry, inert conditions.

3. What alternatives exist for silylation reactions if HMDS is unavailable?

Common alternatives include trimethylchlorosilane (TMCS), N,O-bis(trimethylsilyl)acetamide (BSA), and N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA), though reactivity and selectivity may vary.

4. How should this reagent be stored to maintain its stability?

Store in a tightly sealed container under an inert atmosphere (e.g., nitrogen or argon) at room temperature, away from moisture and heat sources.

5. What safety precautions are necessary when handling this chemical?

Use in a fume hood with proper ventilation, wear nitrile gloves and safety goggles, and avoid inhalation or skin contact due to its corrosive and flammable nature.