Specifications Table

Product Name – 1,1,1,3,3,3-Hexamethyldisilazane, 98%, AcroSeal®
Quantity/Pack Size – 100ML, 1LT
Form – Liquid
Grade – 98% Pure
Application – Silylation reagent, moisture scavenger, GC/MS derivatization

Product Overview

1,1,1,3,3,3-Hexamethyldisilazane (HMDS) is a high-purity silylation reagent with 98% assay, packaged under AcroSeal® protection to ensure maximum stability and shelf life. This volatile, colorless liquid is highly reactive with moisture, making it an excellent choice for applications requiring anhydrous conditions. Its low boiling point (125°C) and high volatility allow for rapid evaporation, leaving behind trimethylsilyl (TMS) derivatives that enhance the volatility and thermal stability of polar compounds in chromatographic analysis. The AcroSeal® packaging prevents contamination from atmospheric moisture, ensuring consistent performance in sensitive analytical procedures. This grade is particularly valued for its minimal impurity profile, which reduces background interference in mass spectrometry and gas chromatography. The reagent’s strong basicity (pKa ~25) enables efficient deprotonation of acidic substrates, facilitating smooth silylation reactions. Its compatibility with most organic solvents further expands its utility in multi-step synthetic protocols.

FAQs

1. What is the shelf life of 1,1,1,3,3,3-Hexamethyldisilazane when stored properly?

When stored unopened in its original AcroSeal® packaging at room temperature, this reagent maintains its specified purity for at least 24 months from the date of manufacture.

2. Can this HMDS grade be used for electron microscopy sample preparation?

The high purity and low moisture content make this grade suitable for critical drying applications in electron microscopy, though specialized protocols may require additional purification steps.

3. What precautions should be taken when handling this chemical?

Always handle in a fume hood due to its volatile nature and potential to release ammonia upon hydrolysis. Use moisture-free glassware and store under inert gas after opening.

4. How does the AcroSeal® packaging benefit this product?

The AcroSeal® system uses a proprietary barrier technology that prevents moisture ingress and oxygen exposure, preserving the reagent’s reactivity and extending its usable life.

5. What alternatives exist for less moisture-sensitive applications?

For applications where extreme anhydrous conditions aren’t critical, trimethylchlorosilane or N,O-bis(trimethylsilyl)acetamide may serve as functional alternatives with different reactivity profiles.