Description
Specifications Table
Product Name – 1,1,1,3,3,3-Hexamethyldisilazane BAKER ANALYZED™ reagent
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – BAKER ANALYZED™ Reagent
Application – Silylation agent, derivatization, surface modification, GC-MS sample preparation
Product Overview
1,1,1,3,3,3-Hexamethyldisilazane (HMDS) is a high-purity silylating agent supplied in BAKER ANALYZED™ reagent grade, designed for applications demanding exceptional reactivity and consistency. This colorless, volatile liquid is highly sensitive to moisture, making it ideal for silylation reactions where water must be excluded to prevent side reactions. Its low molecular weight and high vapor pressure enable rapid evaporation, ensuring efficient derivatization of polar functional groups such as alcohols, amines, and carboxylic acids. The reagent’s high silicon content (25.2%) contributes to its effectiveness in forming trimethylsilyl (TMS) derivatives, which are critical for gas chromatography-mass spectrometry (GC-MS) analysis by enhancing volatility and thermal stability of analytes. The BAKER ANALYZED™ grade guarantees stringent quality control, with lot-specific certificates of analysis verifying purity, identity, and trace impurities. This grade is particularly suited for applications where reproducibility is paramount, such as in synthetic chemistry, materials science, and analytical testing. HMDS is also employed in microelectronics for surface passivation and as a coupling agent in silica-based materials. Its reactivity with hydroxyl groups makes it a preferred choice for modifying glass or silicon surfaces to reduce adhesion or alter wettability. Storage under inert gas and in tightly sealed containers is essential to maintain its integrity, as exposure to atmospheric moisture can lead to hydrolysis and the formation of hexamethyldisiloxane (HMDSO). The 100 ml pack size offers a practical volume for frequent laboratory use, balancing cost efficiency with minimal waste. Compatibility with most organic solvents—except those containing active hydrogen—further extends its utility in diverse experimental setups. For optimal performance, handle in a fume hood and use dry, inert conditions during transfer and storage.
FAQs
1. What is the primary function of 1,1,1,3,3,3-Hexamethyldisilazane in lab applications?
It acts as a silylating agent, converting polar functional groups (like -OH, -NH, -COOH) into trimethylsilyl derivatives to improve volatility and stability for techniques like GC-MS.
2. Can this HMDS reagent be used directly without purification?
The BAKER ANALYZED™ grade is pre-tested for purity and can be used as-received for most applications, though further drying with molecular sieves may be needed for moisture-sensitive reactions.
3. What precautions should be taken when storing this chemical?
Store in a tightly sealed container under dry nitrogen or argon, away from moisture and heat sources. Keep in a well-ventilated, cool area (2–8°C for long-term storage).
4. Is this HMDS compatible with plastic containers or septa?
Avoid prolonged contact with plastics, as HMDS can degrade certain polymers. Use glass containers with PTFE-lined caps for storage and handling.
5. What alternatives exist if HMDS is unavailable for silylation?
Alternatives include N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), trimethylchlorosilane (TMCS), or N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA), though reactivity and byproducts may differ.
