Specifications Table

Product Name – (1,3-Dioxolan-2-ylmethyl)magnesium bromide, 0.5M solution in THF, AcroSeal® Quantity/Pack Size – 100ML, 800ML Form – Liquid (THF solution) Grade – Laboratory Grade Application – Organic synthesis, Grignard reactions, carbon-carbon bond formation

Product Overview

(1,3-Dioxolan-2-ylmethyl)magnesium bromide is a 0.5M Grignard reagent solution in tetrahydrofuran (THF), supplied in moisture-resistant AcroSeal® packaging to ensure stability during storage and handling. This organomagnesium compound is widely recognized for its high reactivity in carbon-carbon bond formation, making it a critical reagent in organic synthesis workflows. The THF solvent enhances solubility while maintaining reagent activity, and the standardized 0.5M concentration allows for precise stoichiometric control in reactions. The AcroSeal® technology provides an additional layer of protection against atmospheric moisture and oxygen, which can degrade Grignard reagents over time. This solution is prepared under stringent conditions to minimize impurities, ensuring consistent performance in sensitive applications. The reagent’s structure, featuring a dioxolane-protected alcohol moiety, enables selective transformations while maintaining compatibility with a broad range of functional groups. Proper handling under inert atmosphere is recommended to preserve reactivity, and the solution should be stored at controlled temperatures to prevent decomposition. This product is ideal for laboratories requiring reliable, high-purity Grignard reagents for synthetic chemistry.

FAQs

1. What is the shelf life of this Grignard reagent in THF?

The solution remains stable for 12 months from the date of manufacture when stored unopened at 2-8°C under inert conditions. Once opened, use within 3 months for optimal reactivity.

2. Can this reagent be used directly without further purification?

The 0.5M solution is supplied as a ready-to-use reagent with minimal impurities. However, for highly sensitive applications, titration to confirm molarity is recommended prior to use.

3. Is this compatible with glassware or are special materials required?

The reagent is compatible with standard borosilicate glassware. Avoid plastic containers or pipettes, as THF may dissolve certain polymers. Use PTFE or glass syringes for dispensing.

4. How should I dispose of unused or expired solution?

Neutralize with isopropanol or a saturated ammonium chloride solution before disposal. Follow local regulations for hazardous chemical waste, as the reagent is flammable and reactive.

5. What alternatives exist if this specific Grignard reagent is unavailable?

For similar reactivity, consider (2-bromoethyl)-1,3-dioxolane followed by in-situ Grignard formation, or explore pre-made alkylmagnesium halides with comparable alkyl chain lengths in THF.