Specifications Table

Product Name – [2-(1-Piperidinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Synthesis grade
Application – Organic synthesis, Grignard reactions

Product Overview

[2-(1-Piperidinylmethyl)phenyl]magnesium bromide is a specialized Grignard reagent supplied as a 0.25M solution in anhydrous tetrahydrofuran (THF). This organomagnesium compound is packaged under nitrogen in AcroSeal® bottles to prevent moisture contamination and ensure maximum reactivity during storage. The reagent’s unique piperidinylmethyl substitution provides enhanced stability compared to traditional Grignard reagents while maintaining high nucleophilicity for carbon-carbon bond formation. The THF solvent is carefully dried and stabilized to prevent premature decomposition, with residual water content maintained below 50 ppm. The solution appears as a clear to pale yellow liquid that may develop slight turbidity upon prolonged storage without affecting performance. Each batch undergoes rigorous quality control testing including titration for active magnesium content and GC-MS analysis to confirm structural integrity. The AcroSeal® packaging features a PTFE-lined septum cap that allows for multiple withdrawals while maintaining an inert atmosphere. This formulation is particularly suitable for reactions requiring precise stoichiometry and minimal side product formation.

FAQs

1. What is the typical shelf life of this Grignard reagent solution?

The solution remains stable for 12 months from the date of manufacture when stored unopened at 2-8°C. Once opened, it should be used within 3 months for optimal performance.

2. Can this reagent be used with other solvents besides THF?

The reagent is specifically formulated in THF for stability. Transferring to other solvents may cause precipitation or decomposition. For alternative solvent systems, consider preparing fresh solutions.

3. What safety precautions should be taken when handling this product?

Handle under inert atmosphere using standard Grignard reagent protocols. The solution is highly flammable and reacts violently with water. Use in a properly ventilated fume hood with appropriate PPE.

4. How should the AcroSeal® bottle be properly stored?

Store upright at 2-8°C in a dry, well-ventilated area away from ignition sources. Keep the bottle tightly sealed when not in use to prevent moisture ingress.

5. What’s the difference between this and standard phenylmagnesium bromide?

The piperidinylmethyl substitution provides enhanced stability and different reactivity profiles in certain transformations compared to unsubstituted phenylmagnesium bromide.