Specifications Table

Product Name – [2-(1-Pyrrolidinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal® Quantity/Pack Size – 50ML Form – Liquid (THF solution) Grade – Reagent Application – Organic synthesis, C-C bond formation

Product Overview

[2-(1-Pyrrolidinylmethyl)phenyl]magnesium bromide is a 0.25M Grignard reagent solution in tetrahydrofuran (THF), designed for high-efficiency organic synthesis applications. The reagent features a pyrrolidinylmethyl-substituted phenyl group, offering enhanced reactivity and selectivity in carbon-carbon bond formation reactions. Packaged in an AcroSeal® bottle, this solution is protected against moisture and air exposure, ensuring long-term stability and consistent performance. The THF solvent is anhydrous and stabilized, minimizing side reactions and maximizing yield in synthetic protocols. This reagent is particularly useful for introducing complex functional groups into target molecules, thanks to its unique structural properties. The 0.25M concentration provides an optimal balance between reactivity and ease of handling, making it suitable for both small-scale and larger synthetic procedures. The AcroSeal® packaging system features a septum cap, allowing for convenient syringe extraction without compromising the integrity of the reagent. This product is manufactured under strict quality control to ensure batch-to-batch consistency, with rigorous testing for active magnesium content and solvent purity. The reagent’s stability is further enhanced by the use of high-purity starting materials and controlled reaction conditions during production.

FAQs

1. How should this Grignard reagent be stored to maintain its reactivity?

Store the sealed bottle at 2-8°C in a dry, inert atmosphere. Avoid exposure to air or moisture, as this will decompose the reagent. Keep the container tightly closed when not in use and handle under nitrogen or argon gas for best results.

2. Is this reagent compatible with other common organic solvents besides THF?

The reagent is specifically prepared in THF, which is the most common solvent for Grignard reagents due to its ability to stabilize the organomagnesium species. While it can be used in ether solutions, transferring it to other solvents may affect its reactivity and stability.

3. What precautions should be taken when handling this 0.25M solution?

This reagent is highly moisture-sensitive and pyrophoric. Always handle it in a fume hood using dry glassware and under an inert atmosphere. Wear appropriate protective equipment, including gloves and safety goggles, and avoid contact with water or air.

4. Can this reagent be used for large-scale synthesis, or is it limited to small-scale reactions?

The 0.25M concentration makes it suitable for both small-scale and larger synthesis applications. For bulk reactions, multiple bottles can be used, but ensure proper scaling calculations to maintain reaction stoichiometry and efficiency.

5. What is the typical shelf life of this Grignard reagent when stored properly?

When stored unopened at 2-8°C in its original AcroSeal® packaging, this reagent typically maintains its specified reactivity for at least 12 months from the date of manufacture. Always check the label for the exact expiration date.