Specifications Table

Product Name – [2-(4-Morpholinylmethyl)phenyl]magnesium bromide, 0.25M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Reagent Grade
Application – Organic synthesis, Grignard reactions, C-C coupling

Product Overview

[2-(4-Morpholinylmethyl)phenyl]magnesium bromide is a specialized 0.25M Grignard reagent solution in anhydrous tetrahydrofuran (THF), designed for high-efficiency organic synthesis. The AcroSeal® packaging ensures maximum protection against moisture and oxygen, preserving the reagent’s reactivity for critical applications. This solution maintains a minimum 98% purity, with the morpholinylmethyl phenyl structure enabling selective carbon-carbon bond formation in complex molecular assemblies. The THF solvent is rigorously dried to <50ppm water content, preventing side reactions that could compromise yield. The amber glass bottle with PTFE-lined cap provides additional stability during storage and handling. Each batch undergoes GC-MS analysis to confirm concentration and absence of bromine impurities. The reagent's moderate basicity (pKa ~38) allows compatibility with a wide range of electrophiles while maintaining sufficient nucleophilicity for challenging coupling reactions. The solution's deep red color serves as a visual indicator of its active state, fading only upon complete reaction consumption.

FAQs

1. What is the exact molarity tolerance for this Grignard solution?

The solution is standardized to 0.25M ±0.01M, with batch-specific certificates of analysis provided for each shipment. The narrow tolerance ensures reproducible reaction stoichiometry in multi-step syntheses.

2. Can this reagent be used with water-sensitive substrates?

Yes, the anhydrous THF solvent and AcroSeal® packaging maintain water content below 50ppm, making it suitable for moisture-sensitive transformations. However, we recommend additional drying of reaction vessels when working with extremely hygroscopic substrates.

3. What alternatives exist for similar phenylmagnesium reagents?

For comparable reactivity, consider 4-morpholinophenylmagnesium bromide or 2-(piperidinomethyl)phenylmagnesium chloride, though these may exhibit slightly different steric profiles in crowded reaction centers.

4. How should unused solution be stored for maximum shelf life?

Store unopened bottles at 2-8°C under nitrogen atmosphere. Once opened, maintain under positive argon pressure and use within 3 months. The PTFE-lined cap should be tightly secured after each use to prevent solvent evaporation.

5. What’s the typical bromine content in this reagent?

Residual bromine from the preparation process is maintained below 0.5% by weight, as verified by ion chromatography. This low level minimizes potential side reactions in halogen-sensitive systems.