Specifications Table

Product Name – 2-Benzyloxyphenylmagnesium bromide, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Solution (in THF)
Grade – Reagent Grade
Application – Grignard reagent for organic synthesis, C-C bond formation

Product Overview

This 1M solution of 2-Benzyloxyphenylmagnesium bromide in anhydrous THF is a highly reactive Grignard reagent designed for demanding organic synthesis applications. The benzyloxy-substituted phenylmagnesium bromide offers enhanced stability compared to conventional Grignard reagents while maintaining high nucleophilicity for carbon-carbon bond formation. Packaged in AcroSeal® technology, the solution remains protected from moisture and oxygen, ensuring consistent performance even after multiple uses. The reagent’s THF solvent system provides optimal solubility for a wide range of substrates while the 1M concentration offers a balance between reactivity and ease of handling. The product undergoes rigorous quality control to guarantee minimal byproduct formation and high batch-to-batch consistency. Its air-tight packaging eliminates the need for immediate use after opening, reducing waste in research settings. The solution’s stability profile makes it particularly suitable for reactions requiring prolonged addition times or controlled temperature conditions.

FAQs

1. What precautions should be taken when handling this Grignard solution?

Always work under inert atmosphere using standard Schlenk techniques. The solution is highly moisture-sensitive and pyrophoric when exposed to air. Use flame-dried glassware and maintain anhydrous conditions throughout handling and reaction setup.

2. Can this reagent be used for large-scale synthesis?

The 50mL packaging is optimized for laboratory-scale reactions. For larger preparations, multiple bottles can be combined under inert conditions, though reaction kinetics should be monitored as concentration effects may vary with scale.

3. How does the benzyloxy substituent affect reactivity compared to unsubstituted phenylmagnesium bromide?

The benzyloxy group provides electronic stabilization through resonance while maintaining sufficient nucleophilicity. This typically results in cleaner reactions with reduced side product formation compared to unsubstituted analogues, particularly in sterically hindered systems.

4. What is the typical shelf life when stored properly?

When kept unopened in its original AcroSeal® packaging at room temperature, the solution maintains full reactivity for at least 12 months. After opening, use within 3 months for optimal performance, though the sealed container design minimizes degradation.

5. Are there any known incompatibilities with common reaction solvents?

The THF solution is compatible with most aprotic solvents used in organometallic chemistry. Avoid protic solvents like alcohols or water, and test compatibility when combining with highly polar aprotic solvents that may affect the reagent’s solubility profile.