Specifications Table

Product Name – (2-HYDROXYPROPYL)-β-CYCLODEXTRIN (HPBCD)
Quantity/Pack Size – 25 g, 100 g
Form – White to off-white powder
Grade – Laboratory/Reagent Grade
Application – Solubilization, drug delivery research, complexation studies

Product Overview

(2-Hydroxypropyl)-β-Cyclodextrin (HPBCD) is a chemically modified cyclodextrin derivative renowned for its enhanced water solubility and biocompatibility. Unlike native β-cyclodextrin, HPBCD exhibits lower toxicity and higher inclusion complex formation efficiency, making it a preferred choice for pharmaceutical, biochemical, and analytical applications. Its unique cavity structure allows it to encapsulate hydrophobic molecules, improving their stability and bioavailability. The reagent-grade HPBCD offered here is synthesized under stringent quality controls to ensure minimal impurities, consistent substitution degrees, and reliable performance in research settings. The powder form dissolves readily in aqueous solutions, facilitating seamless integration into experimental protocols. Its neutral pH compatibility and resistance to enzymatic degradation further extend its utility in long-term studies. Whether used for solubilizing poorly water-soluble compounds, enhancing drug delivery systems, or stabilizing volatile actives, this HPBCD variant delivers reproducible results. The product is packaged in airtight containers to preserve its hygroscopic properties and prevent moisture absorption during storage.

FAQs

1. What is the substitution degree of this HPBCD?

The average molar substitution (MS) ranges between 0.6–0.9 hydroxypropyl groups per glucose unit, ensuring optimal solubility without compromising complexation efficiency.

2. Can HPBCD be autoclaved for sterile applications?

Autoclaving is not recommended as it may degrade the cyclodextrin structure. For sterile use, filter sterilization through 0.22 µm membranes is preferred.

3. How does HPBCD compare to native β-cyclodextrin in toxicity?

HPBCD exhibits significantly lower hemolytic activity and renal toxicity compared to native β-cyclodextrin, making it safer for in vivo and cell culture applications.

4. What solvents is HPBCD soluble in besides water?

While primarily water-soluble, it also dissolves in polar organic solvents like dimethyl sulfoxide (DMSO) and ethanol, though solubility decreases in non-polar solvents.

5. Does this HPBCD contain residual organic solvents from synthesis?

The product undergoes rigorous purification to ensure residual solvent levels comply with pharmacopeial standards (typically <0.1% w/w).

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