Specifications Table

Product Name – 2-Thienylmagnesium bromide, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (solution in THF)
Grade – Laboratory grade
Application – Grignard reagent for organic synthesis

Product Overview

2-Thienylmagnesium bromide is a highly reactive Grignard reagent supplied as a 1M solution in tetrahydrofuran (THF), packaged under AcroSeal® technology to prevent moisture contamination and ensure long-term stability. This organomagnesium compound is widely utilized in organic synthesis for carbon-carbon bond formation, particularly in the preparation of thiophene derivatives, pharmaceutical intermediates, and specialty chemicals. The THF solvent enhances solubility and reactivity, making it suitable for nucleophilic addition and substitution reactions under anhydrous conditions. The AcroSeal® packaging features a tamper-evident seal and inert atmosphere, minimizing degradation during storage and handling. With a concentration of 1M, this solution offers precise stoichiometric control for reproducible results in research and development applications. The reagent’s thiophene ring structure introduces unique electronic properties, enabling selective transformations in complex molecular architectures. Proper handling under inert gas is recommended to maintain purity and prevent side reactions.

FAQs

1. What is the shelf life of 2-Thienylmagnesium bromide in THF?

The solution remains stable for 12 months when stored unopened at 2-8°C under inert conditions. Always check the seal before use.

2. Can this reagent be used in aqueous reaction conditions?

No, 2-Thienylmagnesium bromide decomposes rapidly in water. Reactions must be performed under strictly anhydrous conditions.

3. What alternatives exist for thiophene-based Grignard reagents?

3-Thienylmagnesium bromide or 2-thienyllithium can be considered, though reactivity and selectivity may vary.

4. How should I dispose of excess solution?

Neutralize carefully with isopropanol or a dilute acid solution before disposal following local hazardous waste regulations.

5. Is this compatible with glassware or requires special containers?

Standard borosilicate glassware is suitable, but ensure it’s dry and inert-gas purged to prevent premature decomposition.