Specifications Table

Product Name – 3-Chloro-4-Fluorophenylmagnesium Bromide, 0.5M Solution in THF, AcroSeal® Quantity/Pack Size – 50ML Form – Liquid (Solution in THF) Grade – Reagent Grade Application – Grignard reagent for organic synthesis, halogen-metal exchange

Product Overview

3-Chloro-4-Fluorophenylmagnesium Bromide, 0.5M Solution in THF (AcroSeal®), is a highly reactive Grignard reagent designed for precision in organic synthesis. This air- and moisture-sensitive solution is stabilized in tetrahydrofuran (THF), ensuring optimal reactivity for halogen-metal exchange reactions. The 0.5M concentration provides a balanced reactivity profile, making it suitable for synthesizing complex aromatic compounds with fluorine and chlorine substituents. The AcroSeal® packaging guarantees minimal exposure to atmospheric contaminants, preserving the reagent’s integrity until use. This reagent-grade solution is ideal for researchers requiring consistent performance in nucleophilic addition, coupling, or substitution reactions. Its sealed format minimizes handling risks while maintaining high purity, ensuring reproducible results in demanding laboratory applications. The solution’s stability in THF further enhances its versatility across a range of synthetic protocols.

FAQs

1. What is the shelf life of 3-Chloro-4-Fluorophenylmagnesium Bromide in THF?

When stored unopened in its original AcroSeal® packaging at 2–8°C, the solution retains stability for up to 12 months. Avoid prolonged exposure to air or moisture.

2. Can this reagent be used for cross-coupling reactions?

Yes, it is effective in cross-coupling reactions like Kumada or Negishi couplings, provided the reaction conditions are optimized for the fluorine and chlorine substituents.

3. Is this solution compatible with glassware, or are special materials required?

Standard borosilicate glassware is suitable, but ensure it is dry and inert (e.g., oven-dried or flame-dried) to prevent premature decomposition of the Grignard reagent.

4. What alternatives exist if this specific Grignard reagent is unavailable?

Alternatives include 4-fluorophenylmagnesium bromide or 3-chlorophenylmagnesium bromide, though reactivity and selectivity may vary due to the absence of the combined fluorine/chlorine substituents.

5. How should unused solution be disposed of?

Neutralize with a dilute acid (e.g., 1M HCl) in a well-ventilated fume hood, then follow local regulations for hazardous chemical disposal. Never discard untreated reagent.