Specifications Table

Product Name – 3-Fluoro-4-methoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Solution (0.5M in THF)
Grade – Synthesis Grade
Application – Organic synthesis, Grignard reactions

Product Overview

This 3-fluoro-4-methoxyphenylmagnesium bromide solution is a specialized 0.5M Grignard reagent dissolved in anhydrous tetrahydrofuran (THF) for consistent reactivity in organic synthesis. The 3-fluoro-4-methoxy substitution pattern on the phenyl ring provides unique electronic and steric properties, making it valuable for constructing fluorinated aromatic compounds. Packaged in an AcroSeal® container, the reagent remains protected from moisture and oxygen, preserving its potency until use. The THF solvent is rigorously dried to maintain the reagent’s integrity, while the amber bottle shields the contents from light-induced degradation. This formulation is designed for researchers requiring precise control over fluorinated aromatic substitutions without the need for in-house preparation. The solution’s concentration is optimized for direct use in standard reaction protocols, eliminating the variability associated with solid Grignard reagents. The airtight sealing mechanism ensures minimal exposure during storage and dispensing, reducing waste and maintaining consistent performance across multiple uses.

FAQs

1. What is the typical shelf life of this Grignard solution when stored properly?

The solution maintains its specified concentration for 12 months from the date of manufacture when stored at 2-8°C in its original unopened AcroSeal® container. After opening, use within 3 months for optimal results.

2. Can this reagent be used directly in coupling reactions without additional purification?

The solution is provided at synthesis grade purity and can be used directly in most coupling reactions. However, for highly sensitive applications, additional filtration through a dry inert atmosphere may be beneficial.

3. What safety precautions are recommended when handling this THF solution?

Handle in a well-ventilated fume hood using flame-resistant gloves and safety goggles. THF is highly flammable and the Grignard reagent is moisture-sensitive. Use only with dry glassware and under inert atmosphere when possible.

4. How does the 3-fluoro-4-methoxy substitution affect reactivity compared to unsubstituted phenylmagnesium bromide?

The electron-donating methoxy group at the 4-position increases nucleophilicity while the 3-fluoro substituent provides moderate deactivation through inductive effects. This balance often results in improved selectivity in certain substitution patterns.

5. What is the recommended disposal method for unused solution?

Slowly quench with isopropanol or saturated ammonium chloride solution in a well-ventilated area, then neutralize before disposal according to local regulations for organohalogen compounds.