Specifications Table

Product Name – 3-Methoxybenzylmagnesium chloride, 0.25M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Reagent grade
Application – Grignard reagent for organic synthesis

Product Overview

3-Methoxybenzylmagnesium chloride is a 0.25M solution in tetrahydrofuran (THF), packaged under the AcroSeal® system to prevent moisture contamination and degradation. This Grignard reagent is highly reactive and widely used in organic synthesis for carbon-carbon bond formation, particularly in the preparation of aromatic compounds. The methoxy substituent on the benzyl group enhances nucleophilicity while maintaining stability in anhydrous conditions. The THF solvent ensures solubility and compatibility with a broad range of substrates. The AcroSeal® packaging guarantees air-tight storage, preserving reagent integrity and extending shelf life. This solution is ideal for researchers requiring consistent performance in moisture-sensitive reactions. The reagent’s purity and concentration are optimized for reproducibility in synthetic protocols. Proper handling under inert atmosphere is recommended to maintain reactivity.

FAQs

1. What is the shelf life of 3-Methoxybenzylmagnesium chloride in THF?

When stored unopened in its original AcroSeal® packaging at 2-8°C, the solution remains stable for up to 12 months. Always check for signs of decomposition before use.

2. Can this reagent be used directly without further purification?

The 0.25M solution is provided as a reagent-grade product and is typically used as received. However, titration is recommended to confirm concentration before critical applications.

3. What precautions should be taken during handling?

This reagent is highly moisture-sensitive and pyrophoric. Handle under nitrogen or argon atmosphere using dry syringes or cannula techniques. Avoid exposure to air or water.

4. Is this solution compatible with other common organic solvents?

The THF solution can be diluted with anhydrous ethers (e.g., diethyl ether) or hydrocarbons (e.g., toluene). Avoid protic solvents like alcohols or water, which will decompose the reagent.

5. How should unused reagent be disposed of?

Quench excess reagent slowly with isopropanol or a saturated ammonium chloride solution in a well-ventilated fume hood. Follow local regulations for chemical waste disposal.