Description
Specifications Table
Product Name – 3,5-Difluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 100mL
Form – Liquid (THF solution)
Grade – Reagent grade (≥98% purity)
Application – Grignard reagent for organic synthesis, fluorinated aromatic compound synthesis
Product Overview
This 0.5M 3,5-difluorophenylmagnesium bromide solution in anhydrous tetrahydrofuran (THF) is a specialized Grignard reagent designed for demanding organic synthesis applications. The AcroSeal® packaging ensures exceptional moisture resistance, preserving the reagent’s reactivity by preventing hydrolysis during storage and handling. The reagent’s dual fluorine substitution at the meta positions enhances its utility in preparing fluorinated aromatic compounds, which are critical intermediates in pharmaceutical and agrochemical research. The THF solvent is rigorously dried and stabilized to maintain the reagent’s 0.5M concentration, eliminating the need for titration adjustments. With a minimum purity of 98%, this solution delivers consistent performance in halogen-metal exchange reactions, cross-couplings, and nucleophilic additions. The amber glass bottle with a sure-seal cap provides additional protection against light-induced degradation, while the reagent’s low moisture content (<50 ppm) minimizes side reactions. Ideal for researchers requiring reproducible results in fluorine chemistry, this solution eliminates the hazards associated with preparing Grignard reagents in-house.
FAQs
1. What is the shelf life of this 3,5-difluorophenylmagnesium bromide solution when unopened?
The unopened AcroSeal® bottle has a shelf life of 12 months from the date of manufacture when stored at 2–8°C. The sure-seal packaging prevents moisture ingress, which is the primary degradation pathway for Grignard reagents.
2. Can this reagent be used directly in cross-coupling reactions without further purification?
Yes, the solution is supplied at ≥98% purity and requires no additional purification for most applications. However, for highly sensitive reactions, we recommend verifying the titer via standardized methods like gas volumetric analysis.
3. Is this solution compatible with standard Schlenk line techniques?
Absolutely. The THF solvent and reagent are fully compatible with Schlenk line or glove box handling. The AcroSeal® bottle can be directly connected to inert gas manifolds for anaerobic transfer.
4. What precautions should be taken when storing partially used bottles?
After opening, flush the bottle with argon or nitrogen, reseal tightly, and store at 2–8°C. Avoid repeated exposure to air, as this accelerates decomposition. Use within 3 months of opening for optimal reactivity.
5. Are there alternatives for researchers needing higher concentrations?
For higher concentrations, consider preparing the reagent in situ from 3,5-difluorobromobenzene and magnesium turnings in anhydrous THF. Alternatively, some suppliers offer 1.0M solutions, though stability may vary.
