Specifications Table

Product Name – 3,5-Dimethyl-4-methoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – AcroSeal® (air-sensitive)
Application – Grignard reagent for organic synthesis

Product Overview

3,5-Dimethyl-4-methoxyphenylmagnesium bromide is a specialized Grignard reagent supplied as a 0.5M solution in anhydrous THF, ensuring stability and reactivity for demanding organic synthesis. The AcroSeal® packaging guarantees protection against moisture and oxygen, preserving reagent integrity for consistent performance in carbon-carbon bond formation, nucleophilic additions, and other critical reactions. This solution is meticulously prepared to maintain precise concentration, eliminating the need for titration before use. The THF solvent is rigorously dried and distilled to prevent side reactions, while the dimethyl and methoxy substituents on the phenyl ring provide unique steric and electronic properties that influence reaction selectivity. Ideal for researchers requiring reliable, high-purity organomagnesium compounds, this reagent offers excellent solubility in ethereal solvents and predictable behavior in complex synthetic pathways. The sealed packaging system minimizes exposure to atmospheric contaminants during storage and handling.

FAQs

1. How should I store this Grignard reagent to maintain its potency?

Store unopened bottles at 2-8°C in a dry, inert atmosphere. Once opened, use immediately or store under nitrogen with a septum cap to prevent degradation from moisture.

2. What precautions should I take when handling this THF solution?

Always work in a fume hood with proper PPE. THF is highly flammable and the reagent is moisture-sensitive. Use oven-dried glassware and maintain an inert atmosphere during transfers.

3. Can this reagent be used for large-scale synthesis?

The 50mL pack size is optimized for lab-scale reactions. For larger quantities, consider multiple units or contact us for bulk options with appropriate safety documentation.

4. What’s the typical shelf life of this AcroSeal® product?

When stored properly in unopened packaging, the reagent maintains its specified concentration for 12 months from the date of manufacture. Check the label for exact expiration.

5. How does the methoxy substituent affect this Grignard’s reactivity?

The para-methoxy group increases electron density on the phenyl ring through resonance, making the reagent more nucleophilic compared to unsubstituted phenylmagnesium bromide while maintaining good stability.