Description
Specifications Table
Product Name – 4-Biphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid (THF solution)
Grade – Reagent grade
Application – Grignard reagent for organic synthesis
Product Overview
This 0.5M 4-Biphenylmagnesium bromide solution in THF is a highly reactive Grignard reagent designed for demanding organic synthesis applications. The AcroSeal® packaging ensures moisture-free storage and precise dispensing, eliminating contamination risks during air-sensitive reactions. The reagent is stabilized in anhydrous tetrahydrofuran (THF), maintaining consistent molar concentration for reproducible results. Its biphenyl structure provides unique reactivity profiles compared to simpler arylmagnesium halides, making it ideal for synthesizing complex aromatic compounds. The solution is filtered through 0.2µm membranes to remove particulates, guaranteeing analytical purity. Each batch undergoes rigorous Karl Fischer titration to verify water content below 50ppm. The amber glass bottle with PTFE-lined cap prevents solvent evaporation and atmospheric exposure. This reagent is particularly valued for its ability to form carbon-carbon bonds with high regioselectivity in cross-coupling reactions.
FAQs
1. What precautions should be taken when handling this Grignard reagent?
Always work under inert atmosphere using Schlenk techniques or glove boxes. The solution is highly flammable and reacts violently with water. Use dry glassware and moisture-free solvents to prevent decomposition.
2. Can this reagent be used with other solvents besides THF?
The solution is specifically stabilized in THF. Transferring to other solvents may cause precipitation or altered reactivity. For alternative solvent systems, consider preparing fresh solutions from solid 4-biphenylmagnesium bromide.
3. How should unused solution be stored for maximum shelf life?
Store unopened bottles at 2-8°C in a desiccator or under nitrogen atmosphere. Once opened, reseal immediately and use within 3 months. Avoid freeze-thaw cycles as this may cause solvent separation.
4. What analytical methods confirm the reagent’s concentration?
The 0.5M concentration is verified via complexometric titration with EDTA after hydrolysis. Residual water content is measured by Karl Fischer titration, while GC-MS confirms solvent purity and absence of degradation products.
5. Are there any known incompatibilities with common lab materials?
The reagent reacts with protic solvents, acids, and oxidizing agents. Avoid contact with rubber septa or plasticizers – use only PTFE or glass components. The solution may etch sodium glass over prolonged storage.
