Description
Specifications Table
Product Name – 4-Chlorobenzoyl chloride
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – Synthesis Grade
Application – Organic synthesis, acylation reactions, pharmaceutical intermediates
Product Overview
4-Chlorobenzoyl chloride is a high-purity, synthesis-grade reagent widely used in organic chemistry for acylation reactions, pharmaceutical intermediates, and specialty chemical synthesis. This clear, pale-yellow liquid offers a minimum purity of 98%, ensuring reliable results in sensitive applications. Its reactive acyl chloride functional group makes it ideal for introducing 4-chlorobenzoyl moieties into molecular structures, facilitating the synthesis of APIs, agrochemicals, and advanced materials. The reagent is stable under recommended storage conditions but reacts vigorously with water, requiring careful handling in dry environments. Its low moisture content (<0.1%) minimizes side reactions, while the consistent batch-to-batch quality ensures reproducibility in multi-step syntheses. The compound’s boiling point of 240°C and density of 1.34 g/mL at 25°C provide predictable behavior in reaction setups. Compatible with most organic solvents, it serves as a versatile building block in heterocyclic chemistry and polymer modifications. Proper storage in tightly sealed containers under inert gas extends shelf life without degradation.
FAQs
1. What is the typical shelf life of 4-Chlorobenzoyl chloride when stored properly?
When stored in a cool, dry place under inert gas with the container tightly sealed, 4-Chlorobenzoyl chloride maintains its specified purity for up to 24 months from the date of manufacture. Exposure to moisture significantly reduces stability.
2. Can this reagent be used directly in aqueous reaction systems?
No, 4-Chlorobenzoyl chloride hydrolyzes rapidly in water, forming 4-chlorobenzoic acid and hydrochloric acid. It should only be used in anhydrous organic solvents or under strictly controlled moisture-free conditions.
3. What safety precautions are essential when handling this chemical?
Always use in a fume hood with proper ventilation, wear nitrile gloves, safety goggles, and a lab coat. The reagent is corrosive and releases toxic fumes (hydrogen chloride) when exposed to moisture. Neutralize spills with sodium bicarbonate solution.
4. How does the chlorine substituent affect reactivity compared to benzoyl chloride?
The electron-withdrawing chlorine at the para position increases the carbonyl carbon’s electrophilicity, making 4-Chlorobenzoyl chloride more reactive than benzoyl chloride in nucleophilic acyl substitution reactions under identical conditions.
5. What analytical techniques confirm the purity of this product?
Standard quality control includes GC-MS for assay determination, Karl Fischer titration for moisture content, and IR spectroscopy to verify the acyl chloride functional group. Certificates of analysis are provided with each batch.
