Specifications Table

Product Name – 4-Chlorophenylmagnesium bromide, 1M solution in THF/toluene, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid solution
Grade – Reagent
Application – Grignard reagent for organic synthesis

Product Overview

4-Chlorophenylmagnesium bromide is a highly reactive Grignard reagent supplied as a 1M solution in tetrahydrofuran (THF) and toluene, ensuring optimal stability and performance in organic synthesis. The AcroSeal® packaging provides an airtight, moisture-resistant barrier, preserving the reagent’s integrity during storage and handling. This solution is ideal for applications requiring precise halogen-metal exchange or carbon-carbon bond formation, thanks to its consistent molar concentration and high purity. The THF/toluene solvent blend enhances solubility while minimizing side reactions, making it a reliable choice for demanding synthetic protocols. The reagent’s stability is further supported by the absence of stabilizing additives, ensuring clean reactivity in sensitive transformations. Whether used in small-scale laboratory experiments or larger preparative reactions, this solution delivers reproducible results with minimal byproduct formation. The AcroSeal® technology also simplifies dispensing, reducing exposure to atmospheric moisture and extending shelf life.

FAQs

1. What is the shelf life of 4-chlorophenylmagnesium bromide in THF/toluene?

When stored unopened in its original AcroSeal® packaging at 2–8°C, the solution retains its specified concentration for up to 12 months. Always check for cloudiness or precipitation before use, as these indicate degradation.

2. Can this reagent be used directly in anhydrous reactions?

Yes, the solution is pre-dried and packaged under inert conditions, making it suitable for anhydrous protocols without further purification. However, verify moisture content via Karl Fischer titration if critical.

3. What precautions should be taken during handling?

Use in a fume hood with nitrogen or argon atmosphere to prevent hydrolysis. Avoid glassware with ground-glass joints unless greased with inert lubricant, as the reagent attacks silicone grease.

4. Is this compatible with polar aprotic solvents like DMF?

The reagent reacts violently with DMF due to its carbonyl group. For solvent compatibility, stick to ethers (THF, diethyl ether) or hydrocarbons (toluene) unless validated for your specific reaction.

5. How does the THF/toluene blend affect reactivity compared to pure THF?

The toluene co-solvent reduces the solution’s basicity, which can suppress side reactions like enolate formation in sensitive substrates. Reactivity toward electrophiles remains high, but induction periods may lengthen slightly.